Opposite effect of linearly polarized light on biosynthesis of interleukin-6 in a human B lymphoid cell line and peripheral human monocytes

M. Fenyö, J. Mandl, A. Falus

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of linearly polarized light (LPL) and diffuse light (DL) on the in vitro interleukin-6 (IL-6) production in a human B lymphoma cell line (BMNH) and peripheral monocytes of healthy volunteers were compared. Our data show that there was a significant increase of IL-6 and IgM production in BMNH after exposure to LPL. The increase in IgM secretion was a consequence of its autocrine regulation by IL-6, since in the presence of anti-IL-6 and anti-IL-6 receptor antibodies the LPL-induced IgM secretion was abolished. In contrast to the stimulatory effect on B cells, exposure of human mononuclear phagocytes to LPL markedly reduced the production of IL-6 induced by subsequent stimulation of cells with bacterial endotoxin (LPS). The inhibition as most pronounced when suboptimal doses of LPS were applied. Under identical experimental conditions, DL had no effect on the IL-6 and IgM production of either B cells or monocytes.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalCell Biology International
Volume26
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Monocytes
Interleukin-6
Lymphocytes
Light
Cell Line
Immunoglobulin M
B-Lymphocytes
Interleukin-6 Receptors
Phagocytes
Endotoxins
Lymphoma
Healthy Volunteers
Antibodies

Keywords

  • B cell
  • Cytokines
  • Interleukin-6
  • Monocyte
  • Polarized light

ASJC Scopus subject areas

  • Cell Biology

Cite this

@article{cb53b97fe929446ea5eb6483292ed8a2,
title = "Opposite effect of linearly polarized light on biosynthesis of interleukin-6 in a human B lymphoid cell line and peripheral human monocytes",
abstract = "The effects of linearly polarized light (LPL) and diffuse light (DL) on the in vitro interleukin-6 (IL-6) production in a human B lymphoma cell line (BMNH) and peripheral monocytes of healthy volunteers were compared. Our data show that there was a significant increase of IL-6 and IgM production in BMNH after exposure to LPL. The increase in IgM secretion was a consequence of its autocrine regulation by IL-6, since in the presence of anti-IL-6 and anti-IL-6 receptor antibodies the LPL-induced IgM secretion was abolished. In contrast to the stimulatory effect on B cells, exposure of human mononuclear phagocytes to LPL markedly reduced the production of IL-6 induced by subsequent stimulation of cells with bacterial endotoxin (LPS). The inhibition as most pronounced when suboptimal doses of LPS were applied. Under identical experimental conditions, DL had no effect on the IL-6 and IgM production of either B cells or monocytes.",
keywords = "B cell, Cytokines, Interleukin-6, Monocyte, Polarized light",
author = "M. Feny{\"o} and J. Mandl and A. Falus",
year = "2002",
doi = "10.1006/cbir.2001.0841",
language = "English",
volume = "26",
pages = "265--269",
journal = "Cell Biology International",
issn = "1065-6995",
publisher = "Portland Press Ltd.",
number = "3",

}

TY - JOUR

T1 - Opposite effect of linearly polarized light on biosynthesis of interleukin-6 in a human B lymphoid cell line and peripheral human monocytes

AU - Fenyö, M.

AU - Mandl, J.

AU - Falus, A.

PY - 2002

Y1 - 2002

N2 - The effects of linearly polarized light (LPL) and diffuse light (DL) on the in vitro interleukin-6 (IL-6) production in a human B lymphoma cell line (BMNH) and peripheral monocytes of healthy volunteers were compared. Our data show that there was a significant increase of IL-6 and IgM production in BMNH after exposure to LPL. The increase in IgM secretion was a consequence of its autocrine regulation by IL-6, since in the presence of anti-IL-6 and anti-IL-6 receptor antibodies the LPL-induced IgM secretion was abolished. In contrast to the stimulatory effect on B cells, exposure of human mononuclear phagocytes to LPL markedly reduced the production of IL-6 induced by subsequent stimulation of cells with bacterial endotoxin (LPS). The inhibition as most pronounced when suboptimal doses of LPS were applied. Under identical experimental conditions, DL had no effect on the IL-6 and IgM production of either B cells or monocytes.

AB - The effects of linearly polarized light (LPL) and diffuse light (DL) on the in vitro interleukin-6 (IL-6) production in a human B lymphoma cell line (BMNH) and peripheral monocytes of healthy volunteers were compared. Our data show that there was a significant increase of IL-6 and IgM production in BMNH after exposure to LPL. The increase in IgM secretion was a consequence of its autocrine regulation by IL-6, since in the presence of anti-IL-6 and anti-IL-6 receptor antibodies the LPL-induced IgM secretion was abolished. In contrast to the stimulatory effect on B cells, exposure of human mononuclear phagocytes to LPL markedly reduced the production of IL-6 induced by subsequent stimulation of cells with bacterial endotoxin (LPS). The inhibition as most pronounced when suboptimal doses of LPS were applied. Under identical experimental conditions, DL had no effect on the IL-6 and IgM production of either B cells or monocytes.

KW - B cell

KW - Cytokines

KW - Interleukin-6

KW - Monocyte

KW - Polarized light

UR - http://www.scopus.com/inward/record.url?scp=0036388708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036388708&partnerID=8YFLogxK

U2 - 10.1006/cbir.2001.0841

DO - 10.1006/cbir.2001.0841

M3 - Article

VL - 26

SP - 265

EP - 269

JO - Cell Biology International

JF - Cell Biology International

SN - 1065-6995

IS - 3

ER -