Opposite changes in carotid versus aortic stiffness during healthy human pregnancy

Beatrix Mersich, János Rigó, Csilla Besenyei, Zsuzsanna Lénárd, Péter Studinger, Márk Kollai

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Systemic arterial compliance has been known to increase during healthy pregnancy, whereas, recently, the carotid artery has been reported to stiffen. To clarify this controversy, we simultaneously measured aortic PWV (pulse wave velocity) and carotid artery elastic parameters in a cohort of pregnant women. Twelve normotensive pregnant women were studied longitudinally during the three trimesters of pregnancy (T1, T2 and T3 respectively) and 12 weeks PP (post-partum). Carotid artery diastolic diameter and pulsatile distension was measured by an echo-wall tracking method and carotid pulse pressure by applanation tonometry. Carotid strain, compliance, distensibility coefficient, stiffness index β, Einc (incremental elastic modulus) and augmentation index were calculated. Aortic PWV was determined to estimate aortic distensibility. All carotid artery elastic parameters indicated significant stiffening from T1 to T3 (1.8 ± 0.2 versus 2.9 ± 0.3 mmHg for Einc), which was reversed after delivery (2.3 ± 0.2 mmHg). Aortic PWV decreased during pregnancy (6.2 ± 0.2 versus 5.4 ± 0.2 m/s) and increased in the PP period (6.7 ± 0.2 m/s). No correlation was found between changes in carotid artery elastic parameters and changes in aortic PWV either from T 1 to T3 or from T3 to PP. The carotid artery exhibits regionally specific stiffening during pregnancy, which appears to represent a qualitatively different change in arterial elastic behaviour.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalClinical science
Volume109
Issue number1
DOIs
Publication statusPublished - Jul 1 2005

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Keywords

  • Aorta
  • Carotid artery
  • Elasticity
  • Pregnancy
  • Stiffness

ASJC Scopus subject areas

  • Medicine(all)

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