OPLC study of retention of 2,3-dihydro-1,5-benzothiazepines on layers impregnated with tricaprylmethylammonium chloride

K. Kovács-Hadady, A. Lévai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The retention behaviour of various 2,3-dihydro-1,5-benzothiazepines was investigated by means of overpressured layer chromatography on silica gel and on alumina layers impregnated with tricapryl-methylammonium chloride (TCMA), with eluents containing methanol and water, but not TCMA. The retention of benzothiazepines, similarly to that of compounds with different chemical structures studied earlier increased with increasing TCMA concentration on the layer, and decreased with increasing methanol content of the eluent. The interactions between the compounds and the capryl groups of the TCMA adsorbed on the layer are basically hydrophobic; for compounds which have strong acidic character ionpairing may occur in the stationary phase. The type, number and positions of the benzothiazepine substituents can change the extent of the retentionincreasing effect of TCMA. This is explained in detail. Impregnation of the silica gel layers with TCMA improved the resolution of the compounds.

Original languageEnglish
Pages (from-to)482-486
Number of pages5
JournalChromatographia
Volume37
Issue number9-10
DOIs
Publication statusPublished - Nov 1993

Fingerprint

Chlorides
Silica Gel
Methanol
Aluminum Oxide
Chromatography
Impregnation
methylamine
1,5-benzothiazepine
Water

Keywords

  • 2,3-Dihydro-1,5-benzothiazepines
  • Overpressured layer chromatography (OPLC)
  • Tricaprylmethylammonium chloride

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

OPLC study of retention of 2,3-dihydro-1,5-benzothiazepines on layers impregnated with tricaprylmethylammonium chloride. / Kovács-Hadady, K.; Lévai, A.

In: Chromatographia, Vol. 37, No. 9-10, 11.1993, p. 482-486.

Research output: Contribution to journalArticle

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