OPLC combined with NIR spectroscopy - A novel technique for pharmaceutical analysis

Ádám Zoltán Dávid, E. Mincsovics, I. Antal, Éva Furdyga, Zsolt Zsigmond, I. Klebovich

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report a new combination of overpressured-layer chromatography (OPLC) with near-infrared (NIR) spectroscopy for pharmaceutical analysis. Different pharmaceutical preparations containing caffeine, paracetamol, and acetylsalicylic acid as model compounds were separated by OPLC. The band density in the solid phase after OPLC was suitable for study of the separated components directly on the layer by NIR spectroscopy. We have demonstrated the applicability of rapid OPLC separation combined with UV densitometry and NIR spectroscopy for both qualitative and quantitative analysis. This OPLC-UV-NIR technique is thus suitable for rapid, nondestructive investigation of multicomponent pharmaceutical preparations and enables a different type of pharmaceutical analysis, e.g. starting-material tests, in-process control, end-product control, stability testing, etc. Another benefit of this newly developed combination of rapid off-line techniques is the possibility of simultaneous collection of qualitative and quantitative chromatographic and spectral information.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalJournal of Planar Chromatography - Modern TLC
Volume19
Issue number111
DOIs
Publication statusPublished - Sep 2006

Fingerprint

Near infrared spectroscopy
Near-Infrared Spectroscopy
Chromatography
Pharmaceutical Preparations
Densitometry
Acetaminophen
Caffeine
Aspirin
Process control
Infrared radiation
Testing
Chemical analysis

Keywords

  • Acetylsalicylic acid
  • Caffeine
  • Off-line OPLC-UV-NIR
  • OPLC
  • Paracetamol

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

OPLC combined with NIR spectroscopy - A novel technique for pharmaceutical analysis. / Dávid, Ádám Zoltán; Mincsovics, E.; Antal, I.; Furdyga, Éva; Zsigmond, Zsolt; Klebovich, I.

In: Journal of Planar Chromatography - Modern TLC, Vol. 19, No. 111, 09.2006, p. 355-360.

Research output: Contribution to journalArticle

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AU - Mincsovics, E.

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AU - Furdyga, Éva

AU - Zsigmond, Zsolt

AU - Klebovich, I.

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