Opiate antagonists reverse the centrally mediated antihypertensive action of propranolol in spontaneously hypertensive rats

Maria D. Ramirez-Gonzalez, C. Farsang, Liouben Tchakarov, George Kunos

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In anesthetized spontaneously hypertensive rats naltrexone, 2 mg/kg i.p., inhibited the hypotension and bradycardia caused by intracisternal injection of (±)-propranolol. Naltrexone and naloxone also reversed the antihypertensive effect of chronic oral treatment with propranolol (60 mg/kg per day from age 4-14 weeks) in unanesthetized spontaneously hypertensive rats, whereas in untreated littermates the opiate antagonists had insignificant effects on blood pressure and heart rate.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalEuropean Journal of Pharmacology
Volume81
Issue number1
DOIs
Publication statusPublished - Jun 16 1982

Fingerprint

Opiate Alkaloids
Naltrexone
Inbred SHR Rats
Propranolol
Antihypertensive Agents
Bradycardia
Naloxone
Hypotension
Heart Rate
Blood Pressure
Injections
Therapeutics

Keywords

  • Endogenous opioids
  • Hypertension
  • Opiate antagonists
  • Propranolol
  • Spontaneously hypertensive rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Opiate antagonists reverse the centrally mediated antihypertensive action of propranolol in spontaneously hypertensive rats. / Ramirez-Gonzalez, Maria D.; Farsang, C.; Tchakarov, Liouben; Kunos, George.

In: European Journal of Pharmacology, Vol. 81, No. 1, 16.06.1982, p. 167-170.

Research output: Contribution to journalArticle

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