Opiate agonists inhibit neurogenic plasma extravasation in the rat

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Neurogenic plasma extravasation (NPE) evoked by antidromic stimulation of the saphenous nerve was inhibited by more than 50% by i.p. administration of the synthetic enkephalin analogue (D-Met2, Pro5)-enkephalinamide, 0.3-10 mg/kg and, to a lesser extent, by morphine. The effect of enkephalinamide (10 mg/kg) was reserved by naloxone (1 mg/kg, s.c.). Evidence is presented that the effect of enkephalinamide was not secondary to haemodynamic changes or alteration of mast cell function. It is suggested that opiate agonists inhibit NPE through specific opiate receptors, located peripherally on sensory nerve endings, by inhibiting the release of mediator(s) responsible for NPE.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - Jul 17 1981


  • Enkephalinamide
  • Morphine
  • Neurogenic plasma extravasation
  • Nociceptive sensory nerves
  • Opiate receptors

ASJC Scopus subject areas

  • Pharmacology

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