Humán petesejtek mélyhutése

Az osztódá si orsó dinamikája a fagyasztás és felengedés alatt

Translated title of the contribution: Oocyte freezing: Spindle dynamics during freezing and thawing

Konc János, Kanyó Katalin, S. Cseh

Research output: Contribution to journalArticle

Abstract

The presentation discusses our study results related to oocyte freezing and spindle dynamics. The investigations by which the first babies were born from frozen oocytes in Hungary, in 2005 are briefly summarized. Up to date, embryos originating from frozen oocytes were transferred into 35 patients thus resulting in 6 clinical pregnancies (6/35; 17.1%). Three patients had miscarriage between 8 to 12 weeks of gestation and four healthy babies were being given birth by three patients (1 twin pregnancy). We achieved a 9.3% (7/57) implantation rate per transferred embryos and 4.8% (7/147) per thawed oocytes. Prior to freezing, the spindle was detected in 82.9% (34/41) of the oocytes. After thawing and 4 hours in vitro culture, just prior to ICSI the spindle could be detected in only 78.9% (30\38) of the oocytes. In 36.6% (n=11) of the spindle positive oocytes the spindle was detected/visualized at the same position inside the oocytes, as prior to freezing. However, in 63.3% (n= 19) of the oocytes, the spindle was found at a different position in the oocytes. In summary, the results obtained by others and by us indicate that the efficiency of oocyte freezing increased during the past years. Therefore - in special circumstances - it can be recommended to be used in cancer patients prior to chemotherapy and/or radiotherapy, and in religious patients who do not want their embryos to be frozen, etc..

Original languageHungarian
Pages (from-to)153-158
Number of pages6
JournalMagyar Noorvosok Lapja
Volume70
Issue number3
Publication statusPublished - 2007

Fingerprint

Freezing
Oocytes
Embryonic Structures
Pregnancy
Twin Pregnancy
Intracytoplasmic Sperm Injections
Hungary
Spontaneous Abortion
Radiotherapy
Parturition
Drug Therapy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Humán petesejtek mélyhutése : Az osztódá si orsó dinamikája a fagyasztás és felengedés alatt. / János, Konc; Katalin, Kanyó; Cseh, S.

In: Magyar Noorvosok Lapja, Vol. 70, No. 3, 2007, p. 153-158.

Research output: Contribution to journalArticle

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abstract = "The presentation discusses our study results related to oocyte freezing and spindle dynamics. The investigations by which the first babies were born from frozen oocytes in Hungary, in 2005 are briefly summarized. Up to date, embryos originating from frozen oocytes were transferred into 35 patients thus resulting in 6 clinical pregnancies (6/35; 17.1{\%}). Three patients had miscarriage between 8 to 12 weeks of gestation and four healthy babies were being given birth by three patients (1 twin pregnancy). We achieved a 9.3{\%} (7/57) implantation rate per transferred embryos and 4.8{\%} (7/147) per thawed oocytes. Prior to freezing, the spindle was detected in 82.9{\%} (34/41) of the oocytes. After thawing and 4 hours in vitro culture, just prior to ICSI the spindle could be detected in only 78.9{\%} (30\38) of the oocytes. In 36.6{\%} (n=11) of the spindle positive oocytes the spindle was detected/visualized at the same position inside the oocytes, as prior to freezing. However, in 63.3{\%} (n= 19) of the oocytes, the spindle was found at a different position in the oocytes. In summary, the results obtained by others and by us indicate that the efficiency of oocyte freezing increased during the past years. Therefore - in special circumstances - it can be recommended to be used in cancer patients prior to chemotherapy and/or radiotherapy, and in religious patients who do not want their embryos to be frozen, etc..",
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