Ontogenetic development of corticotropin-releasing factor (CRF)-containing neural elements in the brain of the chicken during incubation and after hatching

R. Józsa, Sándor Vigh, Béla Mess, Andrew V. Schally

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In chicken embryos of different ages and in young chickens after hatching, neural elements reacting with antibodies generated against synthetic ovine corticotropin-releasing factor (CRF) were studied by means of the peroxidase-anti-peroxidase (PAP) technique at the lightmicroscopic level. CRF-immunoreactivity was first observed in perikarya located in the periventricular part of the hypothalamus on the 14th day of the incubation period. CRF-containing neural elements were detected on the same day of incubation in the external zone of the median eminence, but not in all investigated animals. In extrahypothalamic sites, immunoreactive perikarya were demonstrable in the central gray of the mesencephalon on the 15th day of incubation. Furthermore, immunoreactive cells appeared in other brain regions such as nucleus accumbens and dorsomedial nucleus of the thalamus after hatching. The present observations provide information regarding the functional development of the hypothalamo-hypophyseal-adrenal axis in the chick embryo.

Original languageEnglish
Pages (from-to)681-685
Number of pages5
JournalCell and Tissue Research
Volume244
Issue number3
DOIs
Publication statusPublished - Jun 1986

Fingerprint

Corticotropin-Releasing Hormone
Chickens
Brain
Peroxidase
Mediodorsal Thalamic Nucleus
Median Eminence
Nucleus Accumbens
Chick Embryo
Mesencephalon
Thalamus
Hypothalamus
Sheep
Animals
Embryonic Structures
Antibodies

Keywords

  • Brain
  • Chicken embryo
  • Corticotropin-releasing factor (CRF)
  • Neuropeptide immunocytochemistry
  • Ontogeny

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

Cite this

Ontogenetic development of corticotropin-releasing factor (CRF)-containing neural elements in the brain of the chicken during incubation and after hatching. / Józsa, R.; Vigh, Sándor; Mess, Béla; Schally, Andrew V.

In: Cell and Tissue Research, Vol. 244, No. 3, 06.1986, p. 681-685.

Research output: Contribution to journalArticle

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