Ontogenesis of the three parts of the fetal rat adenohypophysis: A detailed immunohistochemical analysis

Ágnes Nemeskéri, Béla Halász, Ágnes Nemeskéri

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59 Citations (Scopus)


The sequential changes in the histological pattern of anterior pituitary cytodifferentiation of the rat are de-scribed. The first labeled cells were ACTH positive and were detected in the pars tuberalis on postconceptual day 13. On day 14 ACTH cells also appeared in the ventral periphery of the pars distalis. On fetal day 15 the pars tuberalis anlage was characterized by numerous well-stained ACTH cells and by some weakly labeled FSH-β, LH-β, TSH-β, GH and PRL cells while the pars distalis showed only ACTH positivity. On day 16 of gestation the ACTH cells were equally distributed throughout the whole pars distalis, while LH-β, FSH-β, TSH-β, PRL and GH immunoreactive cells were localized either in the ventral region of the pars distalis only or were evenly distributed throughout the pars distalis. The present immunocyto-chemical data suggest that in the pars distalis the hypophyseal cell differentiation follows a clear rostrocaudal, ventrodorsal direction and that the time sequence of the functional differentiation of the adenohypophysis is pars tuberalis. Pars distalis and pars intermedia.

Original languageEnglish
Pages (from-to)534-543
Number of pages10
Issue number5
Publication statusPublished - Jan 1 1988


  • Hypophysis
  • Lmmunocytochemistry
  • Ontogenesis
  • Rat

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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