Intrahepatikus cholostasis tüneteivel kezdödö Philadelphia chromosoma negatív chronikus myeloid leukaemia.

Translated title of the contribution: Onset of Philadelphia chromosome negative chronic myeloid leukemia with symptoms of intrahepatic cholestasis

Z. Döbrönte, M. Bodnár, Z. Löcsei, F. Brittig, L. Varga, L. István

Research output: Contribution to journalArticle

Abstract

The case of a chronic myelogenous leukemia (CML) starting in an unusual form in a young woman is reported. Rapidly progressing icterus was the first and leading symptom of the disease. Simultaneously with the exclusion of the possibility of hepatitis and extrahepatic obstruction of the bile duct the qualitative blood picture roused the suspicion of a myeloproliferative disease. Detailed hematological examinations confirmed Philadelphia chromosome (Ph1) negative CML. Besides the histologically diffuse leukemic infiltration intrahepatic cholostasis could be demonstrated in the background of the icterus. In the chronic and accelerated phase clinical symptoms developing as a consequence of hepatic organic manifestation were dominating. In the authors's case the moderate leukocytosis, initial thrombocytopenia, absence of splenomegaly, early blast-phase and short survival were atypical, characteristic of Ph1 negative CML. The diagnosis and the absence of other associated hepatopathies was supported also by the post-mortem examination. CML beginning with icteric symptoms due to intrahepatic cholostasis is considered as rarity in the literature.

Original languageHungarian
Pages (from-to)2315-2318
Number of pages4
JournalOrvosi Hetilap
Volume130
Issue number43
Publication statusPublished - Oct 22 1989

Fingerprint

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Intrahepatic Cholestasis
Philadelphia Chromosome
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Jaundice
Extrahepatic Cholestasis
Leukemic Infiltration
Blast Crisis
Splenomegaly
Leukocytosis
Thrombocytopenia
Hepatitis
Autopsy
Survival
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Döbrönte, Z., Bodnár, M., Löcsei, Z., Brittig, F., Varga, L., & István, L. (1989). Intrahepatikus cholostasis tüneteivel kezdödö Philadelphia chromosoma negatív chronikus myeloid leukaemia. Orvosi Hetilap, 130(43), 2315-2318.

Intrahepatikus cholostasis tüneteivel kezdödö Philadelphia chromosoma negatív chronikus myeloid leukaemia. / Döbrönte, Z.; Bodnár, M.; Löcsei, Z.; Brittig, F.; Varga, L.; István, L.

In: Orvosi Hetilap, Vol. 130, No. 43, 22.10.1989, p. 2315-2318.

Research output: Contribution to journalArticle

Döbrönte, Z, Bodnár, M, Löcsei, Z, Brittig, F, Varga, L & István, L 1989, 'Intrahepatikus cholostasis tüneteivel kezdödö Philadelphia chromosoma negatív chronikus myeloid leukaemia.', Orvosi Hetilap, vol. 130, no. 43, pp. 2315-2318.
Döbrönte Z, Bodnár M, Löcsei Z, Brittig F, Varga L, István L. Intrahepatikus cholostasis tüneteivel kezdödö Philadelphia chromosoma negatív chronikus myeloid leukaemia. Orvosi Hetilap. 1989 Oct 22;130(43):2315-2318.
Döbrönte, Z. ; Bodnár, M. ; Löcsei, Z. ; Brittig, F. ; Varga, L. ; István, L. / Intrahepatikus cholostasis tüneteivel kezdödö Philadelphia chromosoma negatív chronikus myeloid leukaemia. In: Orvosi Hetilap. 1989 ; Vol. 130, No. 43. pp. 2315-2318.
@article{106c3e5b279344dc8ef9f796ee6c4a4c,
title = "Intrahepatikus cholostasis t{\"u}neteivel kezd{\"o}d{\"o} Philadelphia chromosoma negat{\'i}v chronikus myeloid leukaemia.",
abstract = "The case of a chronic myelogenous leukemia (CML) starting in an unusual form in a young woman is reported. Rapidly progressing icterus was the first and leading symptom of the disease. Simultaneously with the exclusion of the possibility of hepatitis and extrahepatic obstruction of the bile duct the qualitative blood picture roused the suspicion of a myeloproliferative disease. Detailed hematological examinations confirmed Philadelphia chromosome (Ph1) negative CML. Besides the histologically diffuse leukemic infiltration intrahepatic cholostasis could be demonstrated in the background of the icterus. In the chronic and accelerated phase clinical symptoms developing as a consequence of hepatic organic manifestation were dominating. In the authors's case the moderate leukocytosis, initial thrombocytopenia, absence of splenomegaly, early blast-phase and short survival were atypical, characteristic of Ph1 negative CML. The diagnosis and the absence of other associated hepatopathies was supported also by the post-mortem examination. CML beginning with icteric symptoms due to intrahepatic cholostasis is considered as rarity in the literature.",
author = "Z. D{\"o}br{\"o}nte and M. Bodn{\'a}r and Z. L{\"o}csei and F. Brittig and L. Varga and L. Istv{\'a}n",
year = "1989",
month = "10",
day = "22",
language = "Hungarian",
volume = "130",
pages = "2315--2318",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "43",

}

TY - JOUR

T1 - Intrahepatikus cholostasis tüneteivel kezdödö Philadelphia chromosoma negatív chronikus myeloid leukaemia.

AU - Döbrönte, Z.

AU - Bodnár, M.

AU - Löcsei, Z.

AU - Brittig, F.

AU - Varga, L.

AU - István, L.

PY - 1989/10/22

Y1 - 1989/10/22

N2 - The case of a chronic myelogenous leukemia (CML) starting in an unusual form in a young woman is reported. Rapidly progressing icterus was the first and leading symptom of the disease. Simultaneously with the exclusion of the possibility of hepatitis and extrahepatic obstruction of the bile duct the qualitative blood picture roused the suspicion of a myeloproliferative disease. Detailed hematological examinations confirmed Philadelphia chromosome (Ph1) negative CML. Besides the histologically diffuse leukemic infiltration intrahepatic cholostasis could be demonstrated in the background of the icterus. In the chronic and accelerated phase clinical symptoms developing as a consequence of hepatic organic manifestation were dominating. In the authors's case the moderate leukocytosis, initial thrombocytopenia, absence of splenomegaly, early blast-phase and short survival were atypical, characteristic of Ph1 negative CML. The diagnosis and the absence of other associated hepatopathies was supported also by the post-mortem examination. CML beginning with icteric symptoms due to intrahepatic cholostasis is considered as rarity in the literature.

AB - The case of a chronic myelogenous leukemia (CML) starting in an unusual form in a young woman is reported. Rapidly progressing icterus was the first and leading symptom of the disease. Simultaneously with the exclusion of the possibility of hepatitis and extrahepatic obstruction of the bile duct the qualitative blood picture roused the suspicion of a myeloproliferative disease. Detailed hematological examinations confirmed Philadelphia chromosome (Ph1) negative CML. Besides the histologically diffuse leukemic infiltration intrahepatic cholostasis could be demonstrated in the background of the icterus. In the chronic and accelerated phase clinical symptoms developing as a consequence of hepatic organic manifestation were dominating. In the authors's case the moderate leukocytosis, initial thrombocytopenia, absence of splenomegaly, early blast-phase and short survival were atypical, characteristic of Ph1 negative CML. The diagnosis and the absence of other associated hepatopathies was supported also by the post-mortem examination. CML beginning with icteric symptoms due to intrahepatic cholostasis is considered as rarity in the literature.

UR - http://www.scopus.com/inward/record.url?scp=0024976649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024976649&partnerID=8YFLogxK

M3 - Article

VL - 130

SP - 2315

EP - 2318

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 43

ER -