Onkogén-amplifikáció, illetve -deléció és onkoprotein-expresszió immunhisztokémiai vizsgálata papilláris pajzsmirigyrákban

Várkondi Edit, Gyóry Ferenc, Nagy András, Kiss István, I. Ember, Kozma László

Research output: Contribution to journalArticle

Abstract

The aim of the study: Assessment of occurrence and possible prognostic significance of c-myc and Ha-ras amplification, p53 deletion and overexpression of cyclin D1, p53 and p21 in papillary thyroid cancer. Materials and methods: Formalin-fixed, paraffin-embedded tumor tissue from 24 patients were investigated. Dot-blot DNA hybridization was used to detect oncogene amplification or deletion. The expression of oncoproteins was determined by immunohistochemical method. Results: In our samples neither Ha-ras amplification nor p53 deletion were found. Low c-myc amplification (mean: 2.55) occured in 4 cases (17%). p53 protein was detected in 16 samples (66.6%), with p21 expression (χ2=7.02, p2=10.1, p2=5.35, p

Original languageHungarian
Pages (from-to)424-429
Number of pages6
JournalMagyar Onkologia
Volume45
Issue number5
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Oncology

Cite this

Onkogén-amplifikáció, illetve -deléció és onkoprotein-expresszió immunhisztokémiai vizsgálata papilláris pajzsmirigyrákban. / Edit, Várkondi; Ferenc, Gyóry; András, Nagy; István, Kiss; Ember, I.; László, Kozma.

In: Magyar Onkologia, Vol. 45, No. 5, 2001, p. 424-429.

Research output: Contribution to journalArticle

Edit, Várkondi ; Ferenc, Gyóry ; András, Nagy ; István, Kiss ; Ember, I. ; László, Kozma. / Onkogén-amplifikáció, illetve -deléció és onkoprotein-expresszió immunhisztokémiai vizsgálata papilláris pajzsmirigyrákban. In: Magyar Onkologia. 2001 ; Vol. 45, No. 5. pp. 424-429.
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abstract = "The aim of the study: Assessment of occurrence and possible prognostic significance of c-myc and Ha-ras amplification, p53 deletion and overexpression of cyclin D1, p53 and p21 in papillary thyroid cancer. Materials and methods: Formalin-fixed, paraffin-embedded tumor tissue from 24 patients were investigated. Dot-blot DNA hybridization was used to detect oncogene amplification or deletion. The expression of oncoproteins was determined by immunohistochemical method. Results: In our samples neither Ha-ras amplification nor p53 deletion were found. Low c-myc amplification (mean: 2.55) occured in 4 cases (17{\%}). p53 protein was detected in 16 samples (66.6{\%}), with p21 expression (χ2=7.02, p2=10.1, p2=5.35, p",
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AU - Edit, Várkondi

AU - Ferenc, Gyóry

AU - András, Nagy

AU - István, Kiss

AU - Ember, I.

AU - László, Kozma

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AB - The aim of the study: Assessment of occurrence and possible prognostic significance of c-myc and Ha-ras amplification, p53 deletion and overexpression of cyclin D1, p53 and p21 in papillary thyroid cancer. Materials and methods: Formalin-fixed, paraffin-embedded tumor tissue from 24 patients were investigated. Dot-blot DNA hybridization was used to detect oncogene amplification or deletion. The expression of oncoproteins was determined by immunohistochemical method. Results: In our samples neither Ha-ras amplification nor p53 deletion were found. Low c-myc amplification (mean: 2.55) occured in 4 cases (17%). p53 protein was detected in 16 samples (66.6%), with p21 expression (χ2=7.02, p2=10.1, p2=5.35, p

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