One-pot synthesis of N-protected β-chiral amino alcohols

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Abstract

N-tert-butyloxycarbonyl-S-benzyl-cysteine, N-fluorenylmethyloxycarbonyl-alanine-, S-trityl-cysteine-, O-tert-butyl-serine- and O-tertbutyl-tyrosine were converted to the corresponding alcohols via sodium borohydride reduction of their in situ formed methyl esters. Enantiopurity of the products was checked by chiral HPLC method.

Original languageEnglish
Pages (from-to)1815-1820
Number of pages6
JournalSynthetic Communications
Volume33
Issue number11
DOIs
Publication statusPublished - Jan 1 2003

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Keywords

  • Amino alcohols
  • Enantiopurity
  • Reduction

ASJC Scopus subject areas

  • Organic Chemistry

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