A one-pot, solid-state resolution of racemic-trans-2-iodo-cyclohexanol by O,O′-dibenzoyl-(2R,3R)-tartaric acid was performed. By mixing the solid racemate with half an equivalent resolving agent, the (1R,2R)-isomer of the alcohol remains uncomplexed and can be sublimated at lower temperature. By increasing the temperature, the complex decomposes and the (1S,2S)-isomer can be gained as a second fraction of the sublimation and the resolving agent remains back.
- Optical resolution
- Resolution by complex formation
- Solid-phase reactions
ASJC Scopus subject areas
- Organic Chemistry