One-pot resolution of trans-2-iodo-cyclohexanol with O,O′-dibenzoyl- (2R,3R)-tartaric acid in solid phase

C. Kassai, E. Fogassy, D. Kozma

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A one-pot, solid-state resolution of racemic-trans-2-iodo-cyclohexanol by O,O′-dibenzoyl-(2R,3R)-tartaric acid was performed. By mixing the solid racemate with half an equivalent resolving agent, the (1R,2R)-isomer of the alcohol remains uncomplexed and can be sublimated at lower temperature. By increasing the temperature, the complex decomposes and the (1S,2S)-isomer can be gained as a second fraction of the sublimation and the resolving agent remains back.

Original languageEnglish
Pages (from-to)1015-1018
Number of pages4
JournalSynthetic Communications
Volume36
Issue number8
DOIs
Publication statusPublished - Mar 22 2006

Keywords

  • Optical resolution
  • Resolution by complex formation
  • Solid-phase reactions

ASJC Scopus subject areas

  • Organic Chemistry

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