One-generation reproduction toxicity study of Dithane M-45 (Mancozeb) and lead acetate

L. Várnagy, P. Budai, E. Molnár, I. Takács, S. Fejes, M. Albert, M. Dobos-Kovács

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The reproductive toxicity of lead acetate and of a fungicide formulation (Dithane M-45) containing 80% mancozeb was studied on rats. Lead acetate was applied in the feed in the following dose groups: control, 1,000, 5,000 and 10,000 mg/kg of diet. The three treatment groups received, in addition to the above doses of lead acetate, 4,500 mg/kg Dithane M-45 in the diet. The method was based on the OECD Guideline for Testing of Chemicals No. 415 (1981). Clinical symptoms and mortality were not found in the parent generation. The body weight of female animals decreased significantly before the pregnancy period. This tendency was also seen in males after the combination treatment. At the two high dose levels a remarkable body weight increase was seen in the female animals during the lactation period. As a result of treatment, decreased body weight of offspring was measured during the lactation period. No gross pathological changes were seen. Histological examination showed general tubulonephrosis in the experimental animals. It can be established that the administration of Dithane M-45 did not enhance the reproductive toxicity of lead acetate.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalActa Veterinaria Hungarica
Volume50
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

lead acetate
mancozeb
toxicity testing
Reproduction
reproductive toxicology
Body Weight
Lactation
body weight
lactation
dosage
Diet
diet
signs and symptoms (animals and humans)
laboratory animals
fungicides
pregnancy
Guidelines
Pregnancy
Control Groups
Mortality

Keywords

  • Lead acetate
  • Mancozeb
  • Rat
  • Reproduction

ASJC Scopus subject areas

  • veterinary(all)

Cite this

One-generation reproduction toxicity study of Dithane M-45 (Mancozeb) and lead acetate. / Várnagy, L.; Budai, P.; Molnár, E.; Takács, I.; Fejes, S.; Albert, M.; Dobos-Kovács, M.

In: Acta Veterinaria Hungarica, Vol. 50, No. 3, 2002, p. 365-371.

Research output: Contribution to journalArticle

Várnagy, L. ; Budai, P. ; Molnár, E. ; Takács, I. ; Fejes, S. ; Albert, M. ; Dobos-Kovács, M. / One-generation reproduction toxicity study of Dithane M-45 (Mancozeb) and lead acetate. In: Acta Veterinaria Hungarica. 2002 ; Vol. 50, No. 3. pp. 365-371.
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