One-electron reduction of penicillins in relation to the oxidative stress phenomenon

László Szabó, Tünde Tóth, E. Takács, L. Wojnárovits

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Certain bactericidal antibiotics target mitochondrial components and, due to the leakage of electrons from the electron transport chain, one-electron reduction might occur that can lead to intermediates passing the electron to suitable acceptors. This study aimed at investigating the one-electron reduction mechanism of selected penicillin derivatives using pulse radiolysis techniques. Penicillins can accommodate the electron on each of their carbonyl carbon. Ketyl radicals are thus produced, which are reducing agents with possibility to interact with suitable biomolecules. A detailed mechanism of the reduction is reported.

Original languageEnglish
Pages (from-to)29673-29681
Number of pages9
JournalInternational Journal of Molecular Sciences
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 11 2015

Fingerprint

penicillin
Oxidative stress
Penicillins
Oxidative Stress
Electrons
electrons
Pulse Radiolysis
Radiolysis
Reducing Agents
Biomolecules
Reducing agents
Antibiotics
Electron Transport
antibiotics
radiolysis
Carbon
Anti-Bacterial Agents
Derivatives
leakage
carbon

Keywords

  • Antibiotic
  • Hydrated electron
  • Ketyl radical
  • Oxidative stress
  • Penicillin
  • Pulse radiolysis
  • Reactive oxygen species
  • Reduction

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

Cite this

One-electron reduction of penicillins in relation to the oxidative stress phenomenon. / Szabó, László; Tóth, Tünde; Takács, E.; Wojnárovits, L.

In: International Journal of Molecular Sciences, Vol. 16, No. 12, 11.12.2015, p. 29673-29681.

Research output: Contribution to journalArticle

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