One- and two-dimensional gradient-selected hsqmbc nmr experiments for the efficient analysis of long-range heteronuclear coupling constants

R. Thomas Williamson, Brian L. Márquez, William H. Gerwick, K. Kövér

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

Three new gradient-selected NMR experiments for the analysis of long-range heteronuclear coupling constants are presented. They are demonstrated on a series of compounds including sucrose, strychnine and a complex macrolide, phormidolide, isolated from a marine cyanobacterium. These 1D and 2D heteronuclear single quantum multiple bond correlation (HSQMBC) experiments provide pure absorption, antiphase lineshapes for precise, direct measurement of nJ(C,H) coupling constants. The example compounds were chosen to demonstrate the high sensitivity and ease of spectral interpretation provided by these HSQMBC experiments. In addition, suppression of one-bond CH correlations has been introduced into the HSQMBC pulse sequence.

Original languageEnglish
Pages (from-to)265-273
Number of pages9
JournalMagnetic Resonance in Chemistry
Volume38
Issue number4
Publication statusPublished - Apr 2000

Fingerprint

gradients
Strychnine
strychnine
Experiments
Macrolides
Sugar (sucrose)
Sucrose
sucrose
Nuclear magnetic resonance
retarding
methylidyne
nuclear magnetic resonance
sensitivity
pulses
Cyanobacteria
phormidolide

Keywords

  • C NMR
  • H NMR
  • HSQC
  • J-based configuration analysis
  • Long-range heteronuclear coupling constants
  • Macrolide
  • NMR
  • SQC

ASJC Scopus subject areas

  • Chemistry(all)
  • Physical and Theoretical Chemistry
  • Spectroscopy

Cite this

One- and two-dimensional gradient-selected hsqmbc nmr experiments for the efficient analysis of long-range heteronuclear coupling constants. / Williamson, R. Thomas; Márquez, Brian L.; Gerwick, William H.; Kövér, K.

In: Magnetic Resonance in Chemistry, Vol. 38, No. 4, 04.2000, p. 265-273.

Research output: Contribution to journalArticle

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