Oncogenic changes in murine lymphoid tumors induced by in utero exposure to ionizing radiation

K. Lumniczky, S. Antal, E. Unger, E. J. Hidvégi, G. Sáfrány

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Abstract

We have investigated the oncogenic alterations in murine lymphomas induced by in utero exposure to γ-radiation. The expression of the myc oncogene increased in 23% of the tumors. Alterations in the expression of the ras oncogenes and in the p53 tumor suppressor gene were not characteristic. The p53 gene was mutated in a low percentage of the tumors (12%). Ras mutations were not detected. Loss of heterozygosity (LOH) at the p53 locus was found in 30% of the tumors, and LOH at the mts tumor suppressor gene was detected in 23% of lymphomas. Multiple oncogenic changes were infrequent in the investigated tumors. There were no essential differences in the frequency of carcinogenic alterations in spontaneous and γ-radiation-induced lymphomas.

Original languageEnglish
Pages (from-to)158-162
Number of pages5
JournalRadiation Oncology Investigations
Volume5
Issue number3
DOIs
Publication statusPublished - Sep 6 1997

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Keywords

  • Oncogenes
  • Radiation
  • Tumor suppressors

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging

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