Oncogenes and tumor suppressor genes in murine tumors induced by neutron- or gamma-irradiation in utero

Sára Antal, K. Lumniczky, J. Pálfalvi, E. Hidvégi, F. Schneider, G. Sáfrány

Research output: Contribution to journalArticle

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Abstract

Half a century after the A-bomb explosions, the cancer mortality is still increasing in prenatally exposed survivors. In this study, mice were exposed to neutron- or γ-irradiation of different embryonic stages. The tumor incidence increased to 35% after 2.0 Gy γ-irradiation on the 18th day of gestation, compared with 15% in the unirradiated controls. Most of the tumors developed in the lymphoid system, liver, lung and uterus. Some brain tumors were observed in mice irradiated in utero both with neutron and γ-rays, but none were found in the unirradiated controls. The expression of the p53 gene decreased by 2–5-fold in 60% of lung tumors. Allelic losses on chromosome 11 at the p53 locus were observed in 30–40% of the spontaneous and radiation-induced lymphoid tumors and liver adenocarcinomas. In lung tumors, about one-third of the spontaneous adenocarcinomas exhibited allelic losses at the p53 locus not associated with point mutation. This fact may suggest that the loss at one of p53 alleles is an earlier event during carcinogenesis than development of point mutations.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalInternational Congress Series
Volume1236
Issue numberC
DOIs
Publication statusPublished - Jul 1 2002

Fingerprint

Neutrons
Tumor Suppressor Genes
Oncogenes
Neoplasms
Loss of Heterozygosity
Point Mutation
Lung
Adenocarcinoma
Bombs
Chromosomes, Human, Pair 11
Explosions
Liver
p53 Genes
Brain Neoplasms
Uterus
Survivors
Carcinogenesis
Alleles
Radiation
Pregnancy

Keywords

  • Loss of heterozygosity
  • Oncogenes
  • Radiation
  • Suppressor genes
  • Tumor induction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Oncogenes and tumor suppressor genes in murine tumors induced by neutron- or gamma-irradiation in utero. / Antal, Sára; Lumniczky, K.; Pálfalvi, J.; Hidvégi, E.; Schneider, F.; Sáfrány, G.

In: International Congress Series, Vol. 1236, No. C, 01.07.2002, p. 119-122.

Research output: Contribution to journalArticle

Antal, Sára ; Lumniczky, K. ; Pálfalvi, J. ; Hidvégi, E. ; Schneider, F. ; Sáfrány, G. / Oncogenes and tumor suppressor genes in murine tumors induced by neutron- or gamma-irradiation in utero. In: International Congress Series. 2002 ; Vol. 1236, No. C. pp. 119-122.
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