Oncogene patterns in breast and ovarian carcinomas

B. Csokay, J. Papp, I. Besznyak, P. Bosze, Z. Sarosi, J. Toth, Z. Zalay, E. Olah

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Nineteen paraffin-embedded breast cancer tissue samples selected for long survival (more than 5 years) were analysed for detecting the amplification of the c-erbB-2 (Her-2/neu) oncogene by Polymerase Chain Reaction (PCR). Strong correlation was elucidated between c-erbB-2 amplification and survival such correlation was also observed with histopathologic types and nuclear grading. Because of the similarity of the breast and ovarian cancer in the etiology of the diseases, amplification of c-erbB-2, c-myc and Ki-ras genes was examined in 32 ovarian carcinoma samples (stage I-IV). In ovarian carcinomas c-erbB-2 amplification occurred in 34% (11/32) of the fresh tumour samples and correlation between amplification and clinical staging at P < 0.05 significance level was observed. Amplification of c-myc was detected in 9% (3/32) and none of the tumours showed amplification of Ki-ras.

Original languageEnglish
Pages (from-to)593-599
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume19
Issue number6
Publication statusPublished - Dec 1 1993

Keywords

  • Breast carcinoma
  • Oncogenes
  • Ovarian carcinoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Csokay, B., Papp, J., Besznyak, I., Bosze, P., Sarosi, Z., Toth, J., Zalay, Z., & Olah, E. (1993). Oncogene patterns in breast and ovarian carcinomas. European Journal of Surgical Oncology, 19(6), 593-599.