Once-monthly paliperidone palmitate in recently diagnosed and chronic non-acute patients with schizophrenia

L. Hargarter, P. Bergmans, P. Cherubin, S. Keim, A. Conca, A. Serrano-Blanco, I. Bitter, N. Bilanakis, A. Schreiner

Research output: Contribution to journalArticle

10 Citations (Scopus)


Objective: To explore the treatment response, tolerability and safety of once-monthly paliperidone palmitate (PP1M) in non-acute patients switched from oral antipsychotics, stratified by time since diagnosis as recently diagnosed (≤3 years) or chronic patients (>3 years). Research design and methods: Post hoc analysis of a prospective, interventional, single-arm, multicentre, open-label, 6-month study performed in 233 recently diagnosed and 360 chronic patients. Main outcome measures: The proportion achieving treatment response (defined as ≥20% improvement in Positive and Negative Syndrome Scale [PANSS] total score from baseline to endpoint) and maintained efficacy (defined as non-inferiority in the change in PANSS total score at endpoint [Schuirmann’s test]). Results: 71.4% of recently diagnosed and 59.2% of chronic patients showed a ≥20% decrease in PANSS total score (p = 0.0028 between groups). Changes in PANSS Marder factors, PANSS subscales, and the proportion of patients with a Personal and Social Performance scale (PSP) total score of 71–100 were significantly greater in recently diagnosed compared with chronic patients. PP1M was well tolerated, presenting no unexpected safety findings. Conclusion: These data show that recently diagnosed patients treated with PP1M had a significantly higher treatment response and improved functioning, as assessed by the PSP total score, than chronic patients.

Original languageEnglish
Pages (from-to)1043-1053
Number of pages11
JournalExpert Opinion on Pharmacotherapy
Issue number8
Publication statusPublished - May 23 2016



  • LAI
  • Long-acting injectable antipsychotic
  • paliperidone palmitate
  • schizophrenia
  • treatment response

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Hargarter, L., Bergmans, P., Cherubin, P., Keim, S., Conca, A., Serrano-Blanco, A., Bitter, I., Bilanakis, N., & Schreiner, A. (2016). Once-monthly paliperidone palmitate in recently diagnosed and chronic non-acute patients with schizophrenia. Expert Opinion on Pharmacotherapy, 17(8), 1043-1053. https://doi.org/10.1080/14656566.2016.1174692