On triazoles XLIV [1]. Synthesis of new ring systems containing imidazo[2′, 1′:3, 4][1, 2, 4]triazolo[1, 5-a]pyrimidine and imidazo[1′, 2′:2, 3][1, 2, 4]triazolo[1, 5-a]pyrimidine skeleton

Gábor Berecz, József Reiter, Gyula Argay, Alajos Kálmán

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Ring transformation of 2-cyanoimido-3-methyl-1, 3-oxazolidine (10) yielded 5-amino-3-[N-(2-hydroxyethyl)-N-methyl] amino-1H-1, 2, 4-triazole (6) that was ring closed with different β-keto esters to 2-[N-(2-hydroxyethyl)-N-methyl]amino-1, 2, 4-triazolo[1, 5-a]pyrimidinones (4). Cyclisation of derivatives 4 led to imidazo[2′, 1′:3, 4][1, 2, 4]triazolo[1, 5-a]pyrimidines (2) and imidazo[1′, 2′:2, 3][1, 2, 4]triazolo[1, 5-a]pyrimidines (3) representing 10 novel ring systems, Besides spectroscopical evidence of structure of derivatives 2 and 3 X-ray diffraction analysis of derivative 2b was also performed.

Original languageEnglish
Pages (from-to)319-325
Number of pages7
JournalJournal of Heterocyclic Chemistry
Volume39
Issue number2
DOIs
Publication statusPublished - Jan 1 2002

ASJC Scopus subject areas

  • Organic Chemistry

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