On the use of post-transcriptional processing elements in transgenes

C. B.A. Whitelaw, L. Hiripi, E. Farini, M. L. Opsahl, Z. Bosze

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Abstract

RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalTransgenic Research
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 1 2004

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Keywords

  • Biotechnology
  • Gene silencing
  • RNA processing
  • Transgene
  • Vector

ASJC Scopus subject areas

  • Biotechnology
  • Animal Science and Zoology
  • Agronomy and Crop Science
  • Genetics

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