On the use of post-transcriptional processing elements in transgenes

C. B A Whitelaw, L. Hiripi, E. Farini, M. L. Opsahl, Z. Bösze

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalTransgenic Research
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 2004

Fingerprint

Transgenes
transgenes
RNA
Gene Silencing
gene silencing
breasts
Breast
cells

Keywords

  • Biotechnology
  • Gene silencing
  • RNA processing
  • Transgene
  • Vector

ASJC Scopus subject areas

  • Genetics
  • Plant Science
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Biotechnology
  • Food Science

Cite this

On the use of post-transcriptional processing elements in transgenes. / Whitelaw, C. B A; Hiripi, L.; Farini, E.; Opsahl, M. L.; Bösze, Z.

In: Transgenic Research, Vol. 13, No. 1, 02.2004, p. 75-79.

Research output: Contribution to journalArticle

Whitelaw, C. B A ; Hiripi, L. ; Farini, E. ; Opsahl, M. L. ; Bösze, Z. / On the use of post-transcriptional processing elements in transgenes. In: Transgenic Research. 2004 ; Vol. 13, No. 1. pp. 75-79.
@article{a510a5ce6ea14ffa845efb1a5dd721aa,
title = "On the use of post-transcriptional processing elements in transgenes",
abstract = "RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.",
keywords = "Biotechnology, Gene silencing, RNA processing, Transgene, Vector",
author = "Whitelaw, {C. B A} and L. Hiripi and E. Farini and Opsahl, {M. L.} and Z. B{\"o}sze",
year = "2004",
month = "2",
doi = "10.1023/B:TRAG.0000017178.79427.2c",
language = "English",
volume = "13",
pages = "75--79",
journal = "Transgenic Research",
issn = "0962-8819",
publisher = "Springer Netherlands",
number = "1",

}

TY - JOUR

T1 - On the use of post-transcriptional processing elements in transgenes

AU - Whitelaw, C. B A

AU - Hiripi, L.

AU - Farini, E.

AU - Opsahl, M. L.

AU - Bösze, Z.

PY - 2004/2

Y1 - 2004/2

N2 - RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.

AB - RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.

KW - Biotechnology

KW - Gene silencing

KW - RNA processing

KW - Transgene

KW - Vector

UR - http://www.scopus.com/inward/record.url?scp=1542541208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542541208&partnerID=8YFLogxK

U2 - 10.1023/B:TRAG.0000017178.79427.2c

DO - 10.1023/B:TRAG.0000017178.79427.2c

M3 - Article

VL - 13

SP - 75

EP - 79

JO - Transgenic Research

JF - Transgenic Research

SN - 0962-8819

IS - 1

ER -