On the track of absolute enantioselective catalysis

Luciano Caglioti, Béla Barabás, Francesco Faglioni, Nicola Florini, Paolo Lazzeretti, Marco Maioli, Károly Micskei, Gyula Rábai, Ferdinando Taddei, Claudia Zucchi, Gyula Pályi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The main goal of this communication is to show the utility of empirical approaches combined with mathematical methods in the research regarding the molecular basis of biological chirality. Preparative results (enantiomeric excesses, e.e.) obtained in asymmetric autocatalysis with (AAC) and without (AES) chiral additive were analyzed. Statistical calculations show, that AES (absolute enantioselective synthesis) experiments yield two independent groups of results with prevalence of the R- or S-enantiomer. These are distributed asymmetrically in a second-order beta distribution. Empirical calculations both on AAC and EAS enable to identify the very low (statistical) e.e.-s amplified by AES. These initial e.e.-s show normal distribution. Possible molecular-level reasons of these results were controlled by quantum chemical MO calculations and compatible mechanism(s) are discussed.

Original languageEnglish
Pages (from-to)30-32
Number of pages3
JournalChimica Oggi
Volume26
Issue number5 SUPPL.
Publication statusPublished - Sep 1 2008

    Fingerprint

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Caglioti, L., Barabás, B., Faglioni, F., Florini, N., Lazzeretti, P., Maioli, M., Micskei, K., Rábai, G., Taddei, F., Zucchi, C., & Pályi, G. (2008). On the track of absolute enantioselective catalysis. Chimica Oggi, 26(5 SUPPL.), 30-32.