On the site of action of reserpine on ACTH secretion

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Abstract

The studies were concerned with the site in the CNS of the action of reserpine on pituitary ACTH secretion. The medial basal hypothalamus (MBH) was totally or partially deafferented (interrupting the anterior, the posterior and superior or the posterior connections of the region and leaving intact all the other pathways), the fornix was transected or a lesion was placed in the medial ventral tegmentum of the mesencephalon, and following all these interventions plasma corticosterone levels were determined before reserpine treatment and four hours after drug administration (giving 3.0-3.5 mg/kg b.w. i.p.). In the intact rats reserpine caused a 3-5 fold increase in plasma corticosterone concentration. No elevation in blood corticoid levels occurred if the drug was administered to rats in which the MBH was completely deafferented. Similar results were obtained when only the anterior connections of the MBH were interrupted. In contrast, severance of the afferents coming to the MBH from both sides and from above, or from posterior, transection of the fornix, or a lesion in the medial ventral tegmentum of the mesencephalon did not block the mentioned effect of reserpine. The drug given to intact rats for nine days (0.7 mg/kg b.w. daily i.p.) induced a well-known marked increase in adrenal weight. Complete deafferentation of the MBH also interfered with this effect. - The data suggest that (1) the reserpine-induced CRF release is not directly exerted on the MBH; (2) the critical afferents essential for the pituitary ACTH response to reserpine reach the MBH from an anterior direction; (3) hippocampal and mesencephalic structures having direct contact with the MBH are not primarily responsible for the reserpine effect on ACTH.

Original languageEnglish
Pages (from-to)289-300
Number of pages12
JournalJournal of Neural Transmission
Volume33
Issue number4
DOIs
Publication statusPublished - Dec 1972

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Middle Hypothalamus
Reserpine
Adrenocorticotropic Hormone
Corticosterone
Mesencephalon
Pharmaceutical Preparations
Adrenal Cortex Hormones
Weights and Measures

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

On the site of action of reserpine on ACTH secretion. / Lengvári, I.; Halász, B.

In: Journal of Neural Transmission, Vol. 33, No. 4, 12.1972, p. 289-300.

Research output: Contribution to journalArticle

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