On the relationship between head circumference, brain size, prenatal long-chain PUFA/5-methyltetrahydrofolate supplementation and cognitive abilities during childhood

Andrés Catena, Cristina Martínez-Zaldívar, Carolina Diaz-Piedra, Francisco J. Torres-Espínola, Pilar Brandi, Miguel Pérez-García, T. Decsi, Berthold Koletzko, Cristina Campoy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Head circumference in infants has been reported to predict brain size, total grey matter volume (GMV) and neurocognitive development. However, it is unknown whether it has predictive value on regional and subcortical brain volumes. We aimed to explore the relationship between several head circumference measurements since birth and distributions of GMV and subcortical volumes at later childhood. We examined seventy-four, Caucasian, singleton, term-born infants born to mothers randomised to receive fish oil and/or 5-methyltetrahydrofolate or placebo prenatal supplementation. We assessed head circumference at birth and at 4 and 10 years of age and cognitive abilities at 7 years of age. We obtained brain MRI at 10 years of age, on which we performed voxel-based morphometry, cortical surface extraction and subcortical segmentation. Analyses were controlled for sex, age, height, weight, family status, laterality and total intracranial volume. Prenatal supplementation did not affect head circumference at any age, cognitive abilities or total brain volumes. Head circumference at 4 years presented the highest correlation with total GMV, white matter volume and brain surface area, and was also strongly associated with GMV of frontal, temporal and occipital areas, as well as with caudate nucleus, globus pallidus, putamen and thalamus volumes. As relationships between brain volumes in childhood and several outcomes extend into adulthood, we have found that ages between 0 and 4 years as the optimal time for brain growth; postnatal factors might have the most relevant impact on structural maturation of certain cortical areas and subcortical nuclei, independent of prenatal supplementation.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalBritish Journal of Nutrition
DOIs
Publication statusAccepted/In press - Mar 29 2017

Fingerprint

Aptitude
Head
Brain
Parturition
Globus Pallidus
Fish Oils
Caudate Nucleus
Putamen
5-methyltetrahydrofolate
Thalamus
Placebos
Mothers
Weights and Measures
Gray Matter
Growth

Keywords

  • Brain development
  • Children
  • Head circumference
  • MRI
  • Prenatal supplementation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

On the relationship between head circumference, brain size, prenatal long-chain PUFA/5-methyltetrahydrofolate supplementation and cognitive abilities during childhood. / Catena, Andrés; Martínez-Zaldívar, Cristina; Diaz-Piedra, Carolina; Torres-Espínola, Francisco J.; Brandi, Pilar; Pérez-García, Miguel; Decsi, T.; Koletzko, Berthold; Campoy, Cristina.

In: British Journal of Nutrition, 29.03.2017, p. 1-9.

Research output: Contribution to journalArticle

Catena, Andrés ; Martínez-Zaldívar, Cristina ; Diaz-Piedra, Carolina ; Torres-Espínola, Francisco J. ; Brandi, Pilar ; Pérez-García, Miguel ; Decsi, T. ; Koletzko, Berthold ; Campoy, Cristina. / On the relationship between head circumference, brain size, prenatal long-chain PUFA/5-methyltetrahydrofolate supplementation and cognitive abilities during childhood. In: British Journal of Nutrition. 2017 ; pp. 1-9.
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