A No-Spa, 1-(3,4-dietoxibenzil)-6,7-dietoxi-3,4-dihidroizokinolin hidroklorid, pszeudopolimorfiajarol

Translated title of the contribution: On the pseudopolymorphism of No-Spa, 1-(3,4-diethoxy-benzyl)-6,7- diethoxy-3,4-dihydro-isoquinoline hydrochloride

Böcskei Zsolt, Simon Kálmán, Friesz Antal, Menyhárd Dóra, Tuza Timea, Hermecz István

Research output: Contribution to journalArticle

Abstract

The spasmolytic agent No-Spa®, 1-(3,4-diethoxybenzyl)-6,7-diethoxy-3,4- dihydroisoquinoline hydrochloride (1) is a synthetic analogue of the naturally occurring alkaloid papaverine. (1) is prone to form stoichiometric crystalline solvates with a number of solvents causing technological and stability problem. Present paper describes the X-ray structure determination of the hemiethanol, hemibenzene and hemihydrochloride structures being the most important and interesting from both practical and theoretical point of view. The solvate formation is facilitated by the presence of the flexible ethoxy group encapsulating the solvent and by the quasi perpendicular position of the isoquinoline and phenyl group.

Original languageHungarian
Pages (from-to)24-29
Number of pages6
JournalActa pharmaceutica Hungarica
Volume69
Issue number1
Publication statusPublished - Jan 1 1999

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ASJC Scopus subject areas

  • Pharmaceutical Science

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