The LDA-generated anions of cephalosporin sulfoxides may give rise to a mixture'of C-2- and/or C-4-substituted products owing to the delocalized nature of the negative charge. Under optimized conditions 2α-crotonoyl- and 2α-cinnamoylcephalosporin sulfoxides can be obtained in satisfactory yields, and are useful starting materials for cycloaddition reactions leading to novel analogues with β-lactamase or HLE enzyme-inhibiting properties.
|Number of pages||5|
|Journal||Journal of the Chemical Society - Perkin Transactions 1|
|Publication status||Published - Dec 1 1999|
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