On the preparation of 2-substituted cephalosporin sulfoxides via anionic intermediates

László Tamás, Tamás E. Gunda, Fcrcnc Sztaricskai

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Abstract

The LDA-generated anions of cephalosporin sulfoxides may give rise to a mixture'of C-2- and/or C-4-substituted products owing to the delocalized nature of the negative charge. Under optimized conditions 2α-crotonoyl- and 2α-cinnamoylcephalosporin sulfoxides can be obtained in satisfactory yields, and are useful starting materials for cycloaddition reactions leading to novel analogues with β-lactamase or HLE enzyme-inhibiting properties.

Original languageEnglish
Pages (from-to)721-725
Number of pages5
JournalJournal of the Chemical Society - Perkin Transactions 1
Issue number6
Publication statusPublished - Dec 1 1999

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ASJC Scopus subject areas

  • Chemistry(all)

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