The dissolving characteristics of 6 different barbital modifications have been studied. With one exception, the metastable forms dissolved more rapidly than the stable form. The observed differences were not always significant. Substances recrystallized from an acetone-water mixture were less soluble in aqueous solvents than those recrystallized from water. The dissolving characteristics are changed by tabletting, the stable modification being more favorable in this respect. The solubility of barbital A2 was very poor. Consequently, it is not suited for therapeutic use. The dissociation rate was determined by means of the rotating basket method.
|Translated title of the contribution||On the polymorphism of barbiturates in powders and tablets. V. The dissolution of recrystallized barbital substances and their release from tablets|
|Number of pages||4|
|Publication status||Published - Jan 1 1980|
ASJC Scopus subject areas
- Pharmaceutical Science