ZUR POLYMORPHIE DER BARBITURATE IN PULVERN UND TABLETTEN. V. AUFLOSUNG UMKRISTALLISIERTER BARBITAL-SUBSTANZEN UND FREISETZUNG AUS TABLETTEN

Translated title of the contribution: On the polymorphism of barbiturates in powders and tablets. V. The dissolution of recrystallized barbital substances and their release from tablets

K. Hollenbach, K. Pintye-Hodi, G. Kedvessy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The dissolving characteristics of 6 different barbital modifications have been studied. With one exception, the metastable forms dissolved more rapidly than the stable form. The observed differences were not always significant. Substances recrystallized from an acetone-water mixture were less soluble in aqueous solvents than those recrystallized from water. The dissolving characteristics are changed by tabletting, the stable modification being more favorable in this respect. The solubility of barbital A2 was very poor. Consequently, it is not suited for therapeutic use. The dissociation rate was determined by means of the rotating basket method.

Translated title of the contributionOn the polymorphism of barbiturates in powders and tablets. V. The dissolution of recrystallized barbital substances and their release from tablets
Original languageGerman
Pages (from-to)95-98
Number of pages4
JournalPharmazie
Volume35
Issue number2
Publication statusPublished - Jan 1 1980

ASJC Scopus subject areas

  • Pharmaceutical Science

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