On the pharmacological phenocopying of memory mutations in Drosophila: Alkylxanthines accelerate memory decay

Zoltán Asztalos, Marianna Lossos, P. Friedrich

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Theophylline and 3-isobutyl-1-methylxanthine, two cyclic nucleotide phosphodiesterase inhibitors, when fed to wild-type Drosophila adults, cause the rapid decay of learning index after training in a shock-odor learning paradigm. The drugs practically do not affect the olfactory acuity of flies, hence they influence the learning/memory process itself. The time courses of memory decay resemble those of the memory mutants rutabaga and amnesiac and, to a lesser extent, dunce2 and dunceM11. Theophylline further deteriorates the learning performance of dunceM11. Biochemical characterization of the inhibition of the two major phosphodiesterase isoenzymes in Drosophila by theophylline predicts only a slight inhibition of these enzymes in vivo, in accordance with the unchanged level of cAMP in wild-type fly heads during drug feeding. 8-Phenyltheophylline, an adenosine receptor antagonist in mammals, slightly retards memory decay in the wild-type. It is suggested that alkylxanthines induce memory decay in Drosophila by interfering with cAMP dynamics at more than one point of its metabolism.

Original languageEnglish
Pages (from-to)495-511
Number of pages17
JournalBehavior Genetics
Volume21
Issue number5
DOIs
Publication statusPublished - Sep 1991

Fingerprint

Drosophila
mutation
theophylline
deterioration
Pharmacology
learning
Theophylline
Mutation
Learning
Diptera
drug
Hydrotaea irritans
rutabagas
Purinergic P1 Receptor Antagonists
1-Methyl-3-isobutylxanthine
drugs
Brassica napus
cyclic nucleotides
Phosphodiesterase Inhibitors
enzyme inhibition

Keywords

  • cyclic AMP
  • Drosophila
  • memory mutants
  • olfaction
  • phosphodiesterase

ASJC Scopus subject areas

  • Psychology(all)
  • Behavioral Neuroscience
  • Genetics(clinical)
  • Genetics

Cite this

On the pharmacological phenocopying of memory mutations in Drosophila : Alkylxanthines accelerate memory decay. / Asztalos, Zoltán; Lossos, Marianna; Friedrich, P.

In: Behavior Genetics, Vol. 21, No. 5, 09.1991, p. 495-511.

Research output: Contribution to journalArticle

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