On the origin of dynorphin A and α-neo-endorphin in the substantia nigra

Miklós Palkovits, Michael J. Brownstein, Nadav Zamir

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The substantia nigra contains among the highest dynorphin A (Dyn A) and α-neo-endorphin (α-Neo) concentrations in the central nervous system. No dynorphin positive cell bodies are found there, only a dense network of nerve fibers and terminals. The present study provides evidence that the Dyn A and α-Neo in the substantia nigra are in neural processes arising from cells located in the head of the caudate nucleus. This neuronal system has been characterized by assaying Dyn A and α-Neo in the substantia nigra after a number of surgical transections of neuronal pathways in the rat forebrain and midbrain. Fibers containing dynorphins and neo-endorphins seem to pass through the internal capsule, ansa lenticularis, and medial forebrain bundle on their way from the striatum to the substantia nigra.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalNeuropeptides
Volume4
Issue number3
DOIs
Publication statusPublished - May 1984

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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