On the optimization of the shell thickness of superficially porous particles

K. Horváth, Fabrice Gritti, Jacob N. Fairchild, Georges Guiochon

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The thickness of the porous shells of superficially porous particles influences the separation power of columns packed with these packing materials. Models of the mass transfer kinetics across porous adsorbents permit the prediction of the HETP curves of columns packed with particles having shells of different thicknesses, for molecules of different sizes. Decreasing the thickness of the porous layer potentially results in lower values of the " C-term" of the HETP curve and of the minimum of these curves. The Poppe plots calculated under isocratic and gradient conditions show that the separation power of columns packed with superficially porous particles increases significantly with decreasing thickness of the porous layer but this increase is more important for larger than for smaller molecules. The resolution between pairs of compounds increases at constant values of their retention factors when the strength of the eluent must be reduced to compensate for the decrease of their retention that is caused by the reduction of the surface area of the stationary phase. Thus, the separation power of columns packed with superficially porous particles increases with decreasing shell thickness. In contrast, if analysts do not compensate for the retention decrease, the resolution between small molecular weight compounds becomes worse with thin than with thick superficially porous particles. Finally, the importance of using instruments providing low extra-column band broadening contributions is stressed.

Original languageEnglish
Pages (from-to)6373-6381
Number of pages9
JournalJournal of Chromatography A
Volume1217
Issue number41
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Molecular Weight
Molecules
Adsorbents
Mass transfer
Molecular weight
Kinetics

Keywords

  • Extra-column volume
  • General rate model
  • Poppe plot
  • Shell thickness
  • Superficially porous particles

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

On the optimization of the shell thickness of superficially porous particles. / Horváth, K.; Gritti, Fabrice; Fairchild, Jacob N.; Guiochon, Georges.

In: Journal of Chromatography A, Vol. 1217, No. 41, 10.2010, p. 6373-6381.

Research output: Contribution to journalArticle

Horváth, K. ; Gritti, Fabrice ; Fairchild, Jacob N. ; Guiochon, Georges. / On the optimization of the shell thickness of superficially porous particles. In: Journal of Chromatography A. 2010 ; Vol. 1217, No. 41. pp. 6373-6381.
@article{9736568c7ab6407696da717f9584a956,
title = "On the optimization of the shell thickness of superficially porous particles",
abstract = "The thickness of the porous shells of superficially porous particles influences the separation power of columns packed with these packing materials. Models of the mass transfer kinetics across porous adsorbents permit the prediction of the HETP curves of columns packed with particles having shells of different thicknesses, for molecules of different sizes. Decreasing the thickness of the porous layer potentially results in lower values of the {"} C-term{"} of the HETP curve and of the minimum of these curves. The Poppe plots calculated under isocratic and gradient conditions show that the separation power of columns packed with superficially porous particles increases significantly with decreasing thickness of the porous layer but this increase is more important for larger than for smaller molecules. The resolution between pairs of compounds increases at constant values of their retention factors when the strength of the eluent must be reduced to compensate for the decrease of their retention that is caused by the reduction of the surface area of the stationary phase. Thus, the separation power of columns packed with superficially porous particles increases with decreasing shell thickness. In contrast, if analysts do not compensate for the retention decrease, the resolution between small molecular weight compounds becomes worse with thin than with thick superficially porous particles. Finally, the importance of using instruments providing low extra-column band broadening contributions is stressed.",
keywords = "Extra-column volume, General rate model, Poppe plot, Shell thickness, Superficially porous particles",
author = "K. Horv{\'a}th and Fabrice Gritti and Fairchild, {Jacob N.} and Georges Guiochon",
year = "2010",
month = "10",
doi = "10.1016/j.chroma.2010.08.013",
language = "English",
volume = "1217",
pages = "6373--6381",
journal = "Journal of Chromatography",
issn = "0021-9673",
publisher = "Elsevier",
number = "41",

}

TY - JOUR

T1 - On the optimization of the shell thickness of superficially porous particles

AU - Horváth, K.

AU - Gritti, Fabrice

AU - Fairchild, Jacob N.

AU - Guiochon, Georges

PY - 2010/10

Y1 - 2010/10

N2 - The thickness of the porous shells of superficially porous particles influences the separation power of columns packed with these packing materials. Models of the mass transfer kinetics across porous adsorbents permit the prediction of the HETP curves of columns packed with particles having shells of different thicknesses, for molecules of different sizes. Decreasing the thickness of the porous layer potentially results in lower values of the " C-term" of the HETP curve and of the minimum of these curves. The Poppe plots calculated under isocratic and gradient conditions show that the separation power of columns packed with superficially porous particles increases significantly with decreasing thickness of the porous layer but this increase is more important for larger than for smaller molecules. The resolution between pairs of compounds increases at constant values of their retention factors when the strength of the eluent must be reduced to compensate for the decrease of their retention that is caused by the reduction of the surface area of the stationary phase. Thus, the separation power of columns packed with superficially porous particles increases with decreasing shell thickness. In contrast, if analysts do not compensate for the retention decrease, the resolution between small molecular weight compounds becomes worse with thin than with thick superficially porous particles. Finally, the importance of using instruments providing low extra-column band broadening contributions is stressed.

AB - The thickness of the porous shells of superficially porous particles influences the separation power of columns packed with these packing materials. Models of the mass transfer kinetics across porous adsorbents permit the prediction of the HETP curves of columns packed with particles having shells of different thicknesses, for molecules of different sizes. Decreasing the thickness of the porous layer potentially results in lower values of the " C-term" of the HETP curve and of the minimum of these curves. The Poppe plots calculated under isocratic and gradient conditions show that the separation power of columns packed with superficially porous particles increases significantly with decreasing thickness of the porous layer but this increase is more important for larger than for smaller molecules. The resolution between pairs of compounds increases at constant values of their retention factors when the strength of the eluent must be reduced to compensate for the decrease of their retention that is caused by the reduction of the surface area of the stationary phase. Thus, the separation power of columns packed with superficially porous particles increases with decreasing shell thickness. In contrast, if analysts do not compensate for the retention decrease, the resolution between small molecular weight compounds becomes worse with thin than with thick superficially porous particles. Finally, the importance of using instruments providing low extra-column band broadening contributions is stressed.

KW - Extra-column volume

KW - General rate model

KW - Poppe plot

KW - Shell thickness

KW - Superficially porous particles

UR - http://www.scopus.com/inward/record.url?scp=77956725641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956725641&partnerID=8YFLogxK

U2 - 10.1016/j.chroma.2010.08.013

DO - 10.1016/j.chroma.2010.08.013

M3 - Article

C2 - 20828704

AN - SCOPUS:77956725641

VL - 1217

SP - 6373

EP - 6381

JO - Journal of Chromatography

JF - Journal of Chromatography

SN - 0021-9673

IS - 41

ER -