On the location of TRH producing neurons: thyroid response to PTU treatment after stereotaxic interventions in hypothalamus

K. Köves, A. Magyar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Propylthiouracil (PTU) induced goiter formation was studied in rats following various hypothalamic interventions: 1. lesion of thyrotropic area (TA); 2 2. cut behind TA (posterior frontal cut); 3. knife cut through TA (anterior frontal cut); 4. implantation of small piece of razor blade behind TA. PTU treatment was started at various times following the operation and lasted either for ten days or three weeks. Significant, but incomplete inhibition of goiter formation was found after lesion of TA, blade implantation or posterior frontal cut. Posterior frontal cut interfered to a great extent with pituitary TSH response if the drug was administered shortly after the operation. However, the blocking effect of this intervention was very slight when PTU treatment was initiated later than two weeks after the knife cut or when it lasted for three weeks. Goiter formation was prevented only slightly by anterior frontal cut if PTU was given for ten days. However, the blocking effect was more pronounced if PTU was administered for three weeks. It is thus concluded that there are TRH producing neurons in TA and also in other parts of medial basal hypothalamus and, furthermore, that these elements of TA terminate in the anterior part of the median eminence.

Original languageEnglish
Title of host publicationEndocrinologia Experimentalis
Pages247-257
Number of pages11
Volume9
Edition4
Publication statusPublished - 1975

Fingerprint

Propylthiouracil
Hypothalamus
Thyroid Gland
Goiter
Neurons
Blade Implantation
Middle Hypothalamus
Median Eminence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Endocrinology

Cite this

On the location of TRH producing neurons : thyroid response to PTU treatment after stereotaxic interventions in hypothalamus. / Köves, K.; Magyar, A.

Endocrinologia Experimentalis. Vol. 9 4. ed. 1975. p. 247-257.

Research output: Chapter in Book/Report/Conference proceedingChapter

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