On the late antiischaemic action of the stable PgI2 analogue: 7-oxo-PgI2-Na and its possible mode of action

L. Szekeres, M. Koltai, J. Pataricza, I. Takáts, E. Udvary

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Earlier we have shown in the dog model mimicking angina on effort a delayed antiischaemic effect of PgI2 and its stable analogue 7-oxo-PgI2-Na, appearing only when the drug induced marked vasodilatation was over. In the present experiments we could show that the protective effect appears at a time when the blood pressure returned to normal and in addition the marked platelet aggregation inhibitory effect has also faded away. In the rat 7-oxo-PgI2 could substantially diminish vasopressin induced T-wave elevation in the ECG if given 2 hours before administration of vasopressin. In addition it could moderate the vasopressin induced metabolic changes appearing as diminution of the myocardial CP and ATP-level and increase of the myocardial lactate content. A similar metabolic protection was found in the heart of rats pretreated with 7-oxo-PgI2 2 hours before taking myocardial samples and exposing them for 1 minute to ischaemia by incubation in Ringer solution. It is concluded that a direct metabolic and hemodynamic effect could be at least partly responsible for the late antiischaemic effect of 7-oxo-PgI2. This effect was also present in the early phase of experimental myocardial infarction in conscious rats if animals were pretreated with 7-oxo-PgI2 2 hours before occlusion. However, treatment did not increase survival rate and failed to reduce the incidence and severity of arrhythmias.

Original languageEnglish
JournalBiomedica Biochimica Acta
Volume43
Issue number8-9
Publication statusPublished - 1984

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Vasopressins
Rats
Blood pressure
Hemodynamics
Platelets
Electrocardiography
Platelet Aggregation
Vasodilation
Cardiac Arrhythmias
Lactic Acid
Animals
Ischemia
Agglomeration
Adenosine Triphosphate
Myocardial Infarction
Dogs
Blood Pressure
Incidence
Pharmaceutical Preparations
Experiments

ASJC Scopus subject areas

  • Biochemistry

Cite this

On the late antiischaemic action of the stable PgI2 analogue : 7-oxo-PgI2-Na and its possible mode of action. / Szekeres, L.; Koltai, M.; Pataricza, J.; Takáts, I.; Udvary, E.

In: Biomedica Biochimica Acta, Vol. 43, No. 8-9, 1984.

Research output: Contribution to journalArticle

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