On the formation of non-radioactive copper during the production of 64Cu via proton and deuteron-induced nuclear reactions on enriched 64Ni targets

F. Szélecsényi, Gideon F. Steyn, Zoltán Kovács

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Routine production of 64Cu commonly exploits the 64Ni(p,n) or 64Ni(d,2n) reactions. Above specific threshold energies, however, non-radioactive 63Cu and/or 65Cu are also co-produced. The non-radioactive (cold) Cu can significantly decrease the specific activity (SA) of 64Cu-labelled radiopharmaceuticals. Based on nuclear model calculations for the formation of non-radioactive Cu isotopes, theoretical specific activities (TSA) for 64Cu were estimated. Reported current production methods, however, often yield SA values that are lower than the corresponding TSA predictions by more than an order of magnitude. Most of the non-radioactive Cu causing this has been found to originate from sources other than co-production, indicating that there is still significant potential for method improvement.

Original languageEnglish
JournalJournal of Radioanalytical and Nuclear Chemistry
DOIs
Publication statusAccepted/In press - Sep 26 2015

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Nuclear reactions
Deuterium
Protons
Copper
Radiopharmaceuticals
Isotopes

Keywords

  • Ni target
  • ALICE 2014 calculations
  • Non-radioactive Cu formation
  • Proton and deuteron reactions
  • Specific activity of Cu
  • TENDL 2014 library

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Health, Toxicology and Mutagenesis
  • Pollution
  • Public Health, Environmental and Occupational Health
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "Routine production of 64Cu commonly exploits the 64Ni(p,n) or 64Ni(d,2n) reactions. Above specific threshold energies, however, non-radioactive 63Cu and/or 65Cu are also co-produced. The non-radioactive (cold) Cu can significantly decrease the specific activity (SA) of 64Cu-labelled radiopharmaceuticals. Based on nuclear model calculations for the formation of non-radioactive Cu isotopes, theoretical specific activities (TSA) for 64Cu were estimated. Reported current production methods, however, often yield SA values that are lower than the corresponding TSA predictions by more than an order of magnitude. Most of the non-radioactive Cu causing this has been found to originate from sources other than co-production, indicating that there is still significant potential for method improvement.",
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AU - Szélecsényi, F.

AU - Steyn, Gideon F.

AU - Kovács, Zoltán

PY - 2015/9/26

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N2 - Routine production of 64Cu commonly exploits the 64Ni(p,n) or 64Ni(d,2n) reactions. Above specific threshold energies, however, non-radioactive 63Cu and/or 65Cu are also co-produced. The non-radioactive (cold) Cu can significantly decrease the specific activity (SA) of 64Cu-labelled radiopharmaceuticals. Based on nuclear model calculations for the formation of non-radioactive Cu isotopes, theoretical specific activities (TSA) for 64Cu were estimated. Reported current production methods, however, often yield SA values that are lower than the corresponding TSA predictions by more than an order of magnitude. Most of the non-radioactive Cu causing this has been found to originate from sources other than co-production, indicating that there is still significant potential for method improvement.

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