On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies

J. Lekki, Z. Stachura, W. Dabroś, J. Stachura, F. Menzel, T. Reinert, T. Butz, J. Pallon, E. Gontier, M. D. Ynsa, P. Moretto, Z. Kertész, Z. Szikszai, A. Kiss

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 μm in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands.

Original languageEnglish
Pages (from-to)174-177
Number of pages4
JournalNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume260
Issue number1
DOIs
Publication statusPublished - Jul 2007

Fingerprint

Sun hoods
autoradiography
Skin
Microscopic examination
Visualization
Particle size
Ions
Tissue
Nanoparticles
microscopy
nanoparticles
sebaceous glands
ions
hair
penetration
formulations
Autoradiography

Keywords

  • Autoradiography
  • Ion microprobe
  • Nanoparticles
  • Skin penetration
  • Titanium dioxide

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Instrumentation
  • Surfaces and Interfaces

Cite this

On the follicular pathway of percutaneous uptake of nanoparticles : Ion microscopy and autoradiography studies. / Lekki, J.; Stachura, Z.; Dabroś, W.; Stachura, J.; Menzel, F.; Reinert, T.; Butz, T.; Pallon, J.; Gontier, E.; Ynsa, M. D.; Moretto, P.; Kertész, Z.; Szikszai, Z.; Kiss, A.

In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, Vol. 260, No. 1, 07.2007, p. 174-177.

Research output: Contribution to journalArticle

Lekki, J. ; Stachura, Z. ; Dabroś, W. ; Stachura, J. ; Menzel, F. ; Reinert, T. ; Butz, T. ; Pallon, J. ; Gontier, E. ; Ynsa, M. D. ; Moretto, P. ; Kertész, Z. ; Szikszai, Z. ; Kiss, A. / On the follicular pathway of percutaneous uptake of nanoparticles : Ion microscopy and autoradiography studies. In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. 2007 ; Vol. 260, No. 1. pp. 174-177.
@article{f15732424c1d4ca18b9430226a4ae202,
title = "On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies",
abstract = "We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 μm in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands.",
keywords = "Autoradiography, Ion microprobe, Nanoparticles, Skin penetration, Titanium dioxide",
author = "J. Lekki and Z. Stachura and W. Dabroś and J. Stachura and F. Menzel and T. Reinert and T. Butz and J. Pallon and E. Gontier and Ynsa, {M. D.} and P. Moretto and Z. Kert{\'e}sz and Z. Szikszai and A. Kiss",
year = "2007",
month = "7",
doi = "10.1016/j.nimb.2007.02.021",
language = "English",
volume = "260",
pages = "174--177",
journal = "Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms",
issn = "0168-583X",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - On the follicular pathway of percutaneous uptake of nanoparticles

T2 - Ion microscopy and autoradiography studies

AU - Lekki, J.

AU - Stachura, Z.

AU - Dabroś, W.

AU - Stachura, J.

AU - Menzel, F.

AU - Reinert, T.

AU - Butz, T.

AU - Pallon, J.

AU - Gontier, E.

AU - Ynsa, M. D.

AU - Moretto, P.

AU - Kertész, Z.

AU - Szikszai, Z.

AU - Kiss, A.

PY - 2007/7

Y1 - 2007/7

N2 - We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 μm in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands.

AB - We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 μm in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands.

KW - Autoradiography

KW - Ion microprobe

KW - Nanoparticles

KW - Skin penetration

KW - Titanium dioxide

UR - http://www.scopus.com/inward/record.url?scp=34250027287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250027287&partnerID=8YFLogxK

U2 - 10.1016/j.nimb.2007.02.021

DO - 10.1016/j.nimb.2007.02.021

M3 - Article

AN - SCOPUS:34250027287

VL - 260

SP - 174

EP - 177

JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

SN - 0168-583X

IS - 1

ER -