On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies

J. Lekki, Z. Stachura, W. Dabroś, J. Stachura, F. Menzel, T. Reinert, T. Butz, J. Pallon, E. Gontier, M. D. Ynsa, P. Moretto, Z. Kertesz, Z. Szikszai, A. Z. Kiss

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 μm in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands.

Original languageEnglish
Pages (from-to)174-177
Number of pages4
JournalNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume260
Issue number1
DOIs
Publication statusPublished - Jul 1 2007

Keywords

  • Autoradiography
  • Ion microprobe
  • Nanoparticles
  • Skin penetration
  • Titanium dioxide

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Instrumentation

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