On the examination of the pulmonary toxicity of mordenite in rats

E. Tátrai, E. Bacsy, J. Karpati, G. Ungvary

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mordenite, a fibrous-granular type of zeolites, was examined in CFY rats in long term in vivo experiments. After single intratracheal treatment, the lungs, cervical and hilar lymph nodes of the animals were processed at the end of the 1st, 3rd and 6th month and also the 1st year by routine histology, enzyme histochemistry and electron microscopy. After observing the effect of mordenite, dust-storing macrophage foci developed in the interstitium, showing minimal fibrotic tendency by the end of the 1st year. Electron microscopic examinations showed that the dust introduced was stored in the macrophages without structural changes. Energy dispersive X-ray microanalysis indicated that in intracellularly stored dust, the ratio of the two main elements: aluminium and silicon changed in favour of aluminium as compared to the original dust sample. This phenomenon was assessed as an increase in intracellular aluminium concentration, which inhibited fibrosis, exerting an antagonistic effect on silicon.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalPolish Journal of Occupational Medicine and Environmental Health
Volume5
Issue number3
Publication statusPublished - 1992

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Dust
Aluminum
Lung
Silicon
Macrophages
Electron Probe Microanalysis
Zeolites
Histology
Electron Microscopy
Fibrosis
Lymph Nodes
Electrons
mordenite
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

On the examination of the pulmonary toxicity of mordenite in rats. / Tátrai, E.; Bacsy, E.; Karpati, J.; Ungvary, G.

In: Polish Journal of Occupational Medicine and Environmental Health, Vol. 5, No. 3, 1992, p. 237-243.

Research output: Contribution to journalArticle

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