A kutya mellékvesekéreg-túlmuködése (Canine cushing's syndrome) irodalmi áttekintés

Translated title of the contribution: On the canine cushing's syndrome. Survey

Thuróczy Julianna, Huszenicza Gyula, Magdus Melinda, Hargittai Tamir, Papp László, Vörös Károly, Rudas Péter

Research output: Contribution to journalArticle

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Abstract

Based on literature data, pathophysiology, clinical signs, diagnosis and treatment of one of the most frequently observed endocrinopathy in dogs -hyperadrenocorticism -has been summarized. The Canine Cushing's Syndrome (CCS) is due to pituitary-dependent hyperadrenocorticism (PDH) in 80 to 85% and adrenal tumor hyperadrenocorticism (ATH) in 15 to 20% of all the cases, respectively. It can also owing to hormone producing tumor caused by ectopic ACTH overproduction or by iatrogenic CCS. Characteristic features of the disease observed in any breeds and - first of all - in medium aged and older dogs are, as follows: polyuria/polydipsia, polyphagia, lethargy, pendulous abdomen (Fig. 1), myasthenia, alopecia, skin atrophy (Fig. 2), development of comedos (Fig. 3), calcinosis cutis (Fig. 4), as well as reproductive biological disorders. Investigation of urine and blood revealed many non-specific alterations. Hyperadrenocorticism can be suspected according to the clinical symptoms, biochemical investigations and screening tests. Diagnosis of the disease is carried out by the determination of cortisol concentration by RIA, ELISA, HPLC or EIA following ACTH stimulation test and low-dose dexamethasone suppression (LDDS) test. To select an appropriate therapy, differentiation of hyperadrenocorticism of hypophysic or adrenocortical origin can be done by high-dose dexamethasone suppression (HDDS) test, determination of ACTH concentration, UH, CT and scintigraphic investigations. Treatment of hyperadrenocorticism can be carried out by definite destruction of cortisol-producing areas in the adrenal cortex, reversible suspension of its function or surgical removal of adrenal cortex or hypophysis containing the hormone-producing tumor. The most frequently used preparation is Lysodren (mitotane).

Original languageHungarian
Pages (from-to)42-47
Number of pages6
JournalMagyar Allatorvosok Lapja
Volume51
Issue number1
Publication statusPublished - Dec 1 1996

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ASJC Scopus subject areas

  • veterinary(all)

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