On the biophysics of transmembrane signalling

L. Trón, A. Aszalós, M. Balázs, S. A. Mulhern, J. Szöllösi, S. Damjanovich

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Transmembrane signalling involves a number of physical translocations, changes in proximity of membrane elements like receptor subunits, or sequestration of proteins from the membrane. The monitoring of such changes with flow cytometric energy transfer revealed a new putative subunit of the IL-2 receptor and a possible intermolecular interaction between HLA class I and class II antigens. Lateral diffusion of the components of the multi-subunit IL-2 receptor was also followed. Changes in the intracellular pH were considered as a measure of efficient signal transfer in a number of cases. An overview and critical comparison of data is presented in the paper.

Original languageEnglish
Pages (from-to)1075-1080
Number of pages6
JournalMolecular Immunology
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 1988

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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