Olive oil decreases liver damage in rats caused by carbon tetrachloride (CCl4)

B. Szende, F. Timar, B. Hargitai

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Oral carbon tetrachloride (CCl4) poisoning of the liver of male F-344 rats was modified by dissolving CCl4 in various oils (sunflower, corn, fish and olive). After 8 weeks of CCl4 treatment (3 x 0.2 ml/kg body weight every other day, dissolved in aliquots of 0.5 ml of each types of oil) the rats were sacrificed and the ratio of connective tissue in the liver was determined by morphometry after picrosirius staining. The percentage of collagen fibres increased in all CCl4-treated groups compared to the controls. This increase was almost the same (6-8%) in the case of CCl4 dissolved in sunflower, corn or fish oil, but when olive oil was applied as a solvent, the collagen ratio was only 2-4 percent. On the basis of this finding olive oil is considered as less harmful to the liver in acute CCl4 poisoning than other oils.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalExperimental and Toxicologic Pathology
Volume46
Issue number4-5
Publication statusPublished - 1994

Fingerprint

Carbon Tetrachloride Poisoning
Carbon Tetrachloride
Liver
Rats
Corn Oil
Oils
Collagen
Fish Oils
Connective Tissue
Fish
Fishes
Body Weight
Tissue
Staining and Labeling
Fibers
Olive Oil
sunflower seed oil

Keywords

  • carbon tetrachloride
  • liver cirrhosis
  • liver damage, olive oil
  • olive oil, liver damage

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Olive oil decreases liver damage in rats caused by carbon tetrachloride (CCl4). / Szende, B.; Timar, F.; Hargitai, B.

In: Experimental and Toxicologic Pathology, Vol. 46, No. 4-5, 1994, p. 355-359.

Research output: Contribution to journalArticle

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