Oligopeptides interfering with calcium channels inhibit prolactin and growth hormone release by cultured anterior pituitary cells of the rat

Iván Nagy, Gábor B. Makara, Vera Garamvölgyi, Sándor Bajusz, Erzsébet Széll, György Rappay

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A number of oligopeptides, protected at their N termini and possessing an aldehyde residue at their C terminal animo acids, are able to inhibit 45Ca2+ influx into anterior pituitary cells grown in monolayer culture and depolarized with high extracellular potassium concentration. In addition, the same oligopeptides interfere with hormone release, especially with that produced by lactotrophs. Our findings imply that oligopeptides may represent a new class of calcium channel ligands, and the pituitary cells are sensitive targets for them.

Original languageEnglish
Pages (from-to)887-892
Number of pages6
JournalBiochemical Pharmacology
Volume40
Issue number4
DOIs
Publication statusPublished - Aug 15 1990

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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