Olfactory bulb in multiple system atrophy

T. Kovács, Mátyás I. Papp, Nigel J. Cairns, M. Nadeem Khan, Peter L. Lantos

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Olfactory dysfunction is a characteristic clinical sign in Parkinson's disease (PD); it is also present in multiple system atrophy (MSA). The pathological basis of hyposmia or anosmia in PD is well known: the olfactory bulb (OB) contains numerous Lewy bodies and severe neuronal loss is present in the anterior olfactory nucleus (AON). We established that glial cytoplasmic inclusions (GCIs) are present in all the OBs from MSA cases. Their presence in the OB is diagnostic for MSA. Additionally, neuronal loss is present in the AON in MSA. These pathological changes might be responsible for the olfactory dysfunction seen in MSA.

Original languageEnglish
Pages (from-to)938-942
Number of pages5
JournalMovement Disorders
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 1 2003

Fingerprint

Multiple System Atrophy
Olfactory Bulb
Parkinson Disease
Olfaction Disorders
Lewy Bodies
Inclusion Bodies
Neuroglia

Keywords

  • α-synuclein
  • Glial cytoplasmic inclusion
  • Multiple system atrophy
  • Olfactory bulb

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Kovács, T., Papp, M. I., Cairns, N. J., Khan, M. N., & Lantos, P. L. (2003). Olfactory bulb in multiple system atrophy. Movement Disorders, 18(8), 938-942. https://doi.org/10.1002/mds.10466

Olfactory bulb in multiple system atrophy. / Kovács, T.; Papp, Mátyás I.; Cairns, Nigel J.; Khan, M. Nadeem; Lantos, Peter L.

In: Movement Disorders, Vol. 18, No. 8, 01.08.2003, p. 938-942.

Research output: Contribution to journalArticle

Kovács, T, Papp, MI, Cairns, NJ, Khan, MN & Lantos, PL 2003, 'Olfactory bulb in multiple system atrophy', Movement Disorders, vol. 18, no. 8, pp. 938-942. https://doi.org/10.1002/mds.10466
Kovács T, Papp MI, Cairns NJ, Khan MN, Lantos PL. Olfactory bulb in multiple system atrophy. Movement Disorders. 2003 Aug 1;18(8):938-942. https://doi.org/10.1002/mds.10466
Kovács, T. ; Papp, Mátyás I. ; Cairns, Nigel J. ; Khan, M. Nadeem ; Lantos, Peter L. / Olfactory bulb in multiple system atrophy. In: Movement Disorders. 2003 ; Vol. 18, No. 8. pp. 938-942.
@article{2e300cfba04e4c2aba923550203ef1f2,
title = "Olfactory bulb in multiple system atrophy",
abstract = "Olfactory dysfunction is a characteristic clinical sign in Parkinson's disease (PD); it is also present in multiple system atrophy (MSA). The pathological basis of hyposmia or anosmia in PD is well known: the olfactory bulb (OB) contains numerous Lewy bodies and severe neuronal loss is present in the anterior olfactory nucleus (AON). We established that glial cytoplasmic inclusions (GCIs) are present in all the OBs from MSA cases. Their presence in the OB is diagnostic for MSA. Additionally, neuronal loss is present in the AON in MSA. These pathological changes might be responsible for the olfactory dysfunction seen in MSA.",
keywords = "α-synuclein, Glial cytoplasmic inclusion, Multiple system atrophy, Olfactory bulb",
author = "T. Kov{\'a}cs and Papp, {M{\'a}ty{\'a}s I.} and Cairns, {Nigel J.} and Khan, {M. Nadeem} and Lantos, {Peter L.}",
year = "2003",
month = "8",
day = "1",
doi = "10.1002/mds.10466",
language = "English",
volume = "18",
pages = "938--942",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Olfactory bulb in multiple system atrophy

AU - Kovács, T.

AU - Papp, Mátyás I.

AU - Cairns, Nigel J.

AU - Khan, M. Nadeem

AU - Lantos, Peter L.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Olfactory dysfunction is a characteristic clinical sign in Parkinson's disease (PD); it is also present in multiple system atrophy (MSA). The pathological basis of hyposmia or anosmia in PD is well known: the olfactory bulb (OB) contains numerous Lewy bodies and severe neuronal loss is present in the anterior olfactory nucleus (AON). We established that glial cytoplasmic inclusions (GCIs) are present in all the OBs from MSA cases. Their presence in the OB is diagnostic for MSA. Additionally, neuronal loss is present in the AON in MSA. These pathological changes might be responsible for the olfactory dysfunction seen in MSA.

AB - Olfactory dysfunction is a characteristic clinical sign in Parkinson's disease (PD); it is also present in multiple system atrophy (MSA). The pathological basis of hyposmia or anosmia in PD is well known: the olfactory bulb (OB) contains numerous Lewy bodies and severe neuronal loss is present in the anterior olfactory nucleus (AON). We established that glial cytoplasmic inclusions (GCIs) are present in all the OBs from MSA cases. Their presence in the OB is diagnostic for MSA. Additionally, neuronal loss is present in the AON in MSA. These pathological changes might be responsible for the olfactory dysfunction seen in MSA.

KW - α-synuclein

KW - Glial cytoplasmic inclusion

KW - Multiple system atrophy

KW - Olfactory bulb

UR - http://www.scopus.com/inward/record.url?scp=0042975213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042975213&partnerID=8YFLogxK

U2 - 10.1002/mds.10466

DO - 10.1002/mds.10466

M3 - Article

VL - 18

SP - 938

EP - 942

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 8

ER -