Olfactory bulb in multiple system atrophy

Tibor Kovács, Mátyás I. Papp, Nigel J. Cairns, M. Nadeem Khan, Peter L. Lantos

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33 Citations (Scopus)

Abstract

Olfactory dysfunction is a characteristic clinical sign in Parkinson's disease (PD); it is also present in multiple system atrophy (MSA). The pathological basis of hyposmia or anosmia in PD is well known: the olfactory bulb (OB) contains numerous Lewy bodies and severe neuronal loss is present in the anterior olfactory nucleus (AON). We established that glial cytoplasmic inclusions (GCIs) are present in all the OBs from MSA cases. Their presence in the OB is diagnostic for MSA. Additionally, neuronal loss is present in the AON in MSA. These pathological changes might be responsible for the olfactory dysfunction seen in MSA.

Original languageEnglish
Pages (from-to)938-942
Number of pages5
JournalMovement Disorders
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 1 2003

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Keywords

  • Glial cytoplasmic inclusion
  • Multiple system atrophy
  • Olfactory bulb
  • α-synuclein

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Kovács, T., Papp, M. I., Cairns, N. J., Khan, M. N., & Lantos, P. L. (2003). Olfactory bulb in multiple system atrophy. Movement Disorders, 18(8), 938-942. https://doi.org/10.1002/mds.10466