Old pathway - new concept

control of glycolysis by metabolite- modulated dynamic enzyme associations

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The presence and kinetic advantages of heterologous interactions between sequential enzymes has been established. Dynamic interactions between the sub-units of oligomeric enzymes may also affect enzymatic activity. If the interactions are specific for certain oligomeric forms of heterologous enzyme pairs, metabolic flux can be modulated by the state of association of enzymes controlled by participating alternatively in homologous and heterologous interactions. A molecular model including the regulatory role of specific metabolites is suggested for the control of glycolysis by pairwise dynamic enzyme associations.

Original languageEnglish
Pages (from-to)486-490
Number of pages5
JournalTrends in Biochemical Sciences
Volume13
Issue number12
DOIs
Publication statusPublished - 1988

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Glycolysis
Metabolites
Enzymes
Molecular Models
Fluxes
Kinetics

ASJC Scopus subject areas

  • Biochemistry

Cite this

Old pathway - new concept : control of glycolysis by metabolite- modulated dynamic enzyme associations. / Ovádi, J.

In: Trends in Biochemical Sciences, Vol. 13, No. 12, 1988, p. 486-490.

Research output: Contribution to journalArticle

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