Old and new neuroendocrine molecules

Somatostatin, cysteamine, pantethine and kynurenine

L. Vécsei, Zoltón Horváth, Bernadett Tuka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this review is to commemorate Hans Selye, endocrinologist, the most famous researchers of stress and to briefly summarize the major features of somatostatin (SST), cysteamine (CysA) and patethine (PAN) in neuroendocrinological aspect, which are closely related to his scientific work. In addition, some metabolites of kynurenine pathway (KP) were also mentioned in this paper, as new, possible target molecules in neuroendocrinology. R. Guillemin and A. V. Schally were the main pioneers of the discovery of SST in the 1970's. SST primarily is known as an inhibitor of growth hormone secretion and additionally reduces the gastric acid and pepsin release and also the gastroduodenal mucosal blood flow. These effects are very important in the pathophysiology of peptic ulcer bleeding, which is related to the CysA-evoked perforating duodenal ulcer experimental stress model in rats developed by Selye and Szabo. CysA is a naturally occurring duodenal ulcero-gen, which depletes SST in the gastric mucosa and certain brain regions. Furthermore, in addition to depleting SST, CysA also causes adrenocortical necrosis, suggesting an interaction between the central/peripheral nervous system and the neuroendocrine system. The antioxidant PAN, formulated besides the CysA, has similar effects: it attenuates the levels of SST and prolactin in the cerebral cortex and hypothalamus through the accumulation of CysA within cells throughout the body. As new perspectives the KP may be involved in the modulation of neuroendrocrine processes: different agonists and antagonists of glutamate receptors regulate the hypothalamic-pituitary-adrenal axis and kynurenic acid augments the anxiolytic stress responses in neonatal chicks. The pro-inflammatory cytokine-induced and the toxic heavy oil contaminations-evoked alterations in the KP indirectly contribute to the development of neuroendocrine disorders. In summary, there have been highly important developments in neuroendocrinology since the early findings of Selye. Although there are as yet relatively few data about the potential role of kynurenines in neuroendocrinology, the results already achieved are extremely noteworthy and immensely promising.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalIdeggyógyászati szemle
Volume67
Issue number3-4
Publication statusPublished - Mar 3 2014

Fingerprint

Kynurenine
Cysteamine
Somatostatin
Neuroendocrinology
Kynurenic Acid
Excitatory Amino Acid Antagonists
Neurosecretory Systems
Poisons
Pepsin A
Gastric Acid
Anti-Anxiety Agents
Peripheral Nervous System
Duodenal Ulcer
Gastric Mucosa
Peptic Ulcer
Prolactin
Cerebral Cortex
Growth Hormone
Hypothalamus
pantethine

Keywords

  • Cysteamine
  • Kynurenine
  • Pantethine
  • Somatostatin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Old and new neuroendocrine molecules : Somatostatin, cysteamine, pantethine and kynurenine. / Vécsei, L.; Horváth, Zoltón; Tuka, Bernadett.

In: Ideggyógyászati szemle, Vol. 67, No. 3-4, 03.03.2014, p. 107-112.

Research output: Contribution to journalArticle

Vécsei, L. ; Horváth, Zoltón ; Tuka, Bernadett. / Old and new neuroendocrine molecules : Somatostatin, cysteamine, pantethine and kynurenine. In: Ideggyógyászati szemle. 2014 ; Vol. 67, No. 3-4. pp. 107-112.
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