Ofloxacin loaded, in-situ - Gelling, calcium alginate hydrogel in the local treatment of bone and soft tissue infections in orthopaedic surgery

Károly Wellinger, Hristifor Gálity, Kálmán Tóth, P. Szabó-Révész, E. Urbán, Erzsébet Csányi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nowadays in orthopedic surgery -in the treatment of bone and soft tissue infections-there is an increasing claim for improving biodegradable drug delivery systems that can be easily placed into the site of application instead of the currently applied polymethylmethacrylate (PMMA) bone cements, since PMMA has some undesirable side effects. Therefore the aim of the study was to develop an injectable, Ofloxacin-loaded, calcium-crosslinked sodium-alginate based drug delivery system, for local administration of antibiotics. It forms an elastic gel within a short time after injection, while its sustained drug release is controlled by a biodegradable polymer network. In vitro Franz vertical cell diffusion test and in vitro microbiological evaluation of the drug release suggested, that calcium-crosslinked sodium-alginate hydrogels are good candidates for replacement of the currently used non-biodegradable bone cements in certain circumstances.

Original languageEnglish
Pages (from-to)711-720
Number of pages10
JournalFarmacia
Volume60
Issue number5
Publication statusPublished - 2012

Fingerprint

Bone Cements
Soft Tissue Infections
Ofloxacin
Hydrogel
Polymethyl Methacrylate
Drug Delivery Systems
Orthopedics
Bone and Bones
Injections
Hydrogels
Polymers
Gels
Anti-Bacterial Agents
Therapeutics
alginic acid
Drug Liberation
In Vitro Techniques

Keywords

  • Bone cement replacement
  • Drug release
  • In-situ forming hydrogels

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Ofloxacin loaded, in-situ - Gelling, calcium alginate hydrogel in the local treatment of bone and soft tissue infections in orthopaedic surgery. / Wellinger, Károly; Gálity, Hristifor; Tóth, Kálmán; Szabó-Révész, P.; Urbán, E.; Csányi, Erzsébet.

In: Farmacia, Vol. 60, No. 5, 2012, p. 711-720.

Research output: Contribution to journalArticle

Wellinger, Károly ; Gálity, Hristifor ; Tóth, Kálmán ; Szabó-Révész, P. ; Urbán, E. ; Csányi, Erzsébet. / Ofloxacin loaded, in-situ - Gelling, calcium alginate hydrogel in the local treatment of bone and soft tissue infections in orthopaedic surgery. In: Farmacia. 2012 ; Vol. 60, No. 5. pp. 711-720.
@article{82b074644bf4473ebf6be8ff96f6dbe2,
title = "Ofloxacin loaded, in-situ - Gelling, calcium alginate hydrogel in the local treatment of bone and soft tissue infections in orthopaedic surgery",
abstract = "Nowadays in orthopedic surgery -in the treatment of bone and soft tissue infections-there is an increasing claim for improving biodegradable drug delivery systems that can be easily placed into the site of application instead of the currently applied polymethylmethacrylate (PMMA) bone cements, since PMMA has some undesirable side effects. Therefore the aim of the study was to develop an injectable, Ofloxacin-loaded, calcium-crosslinked sodium-alginate based drug delivery system, for local administration of antibiotics. It forms an elastic gel within a short time after injection, while its sustained drug release is controlled by a biodegradable polymer network. In vitro Franz vertical cell diffusion test and in vitro microbiological evaluation of the drug release suggested, that calcium-crosslinked sodium-alginate hydrogels are good candidates for replacement of the currently used non-biodegradable bone cements in certain circumstances.",
keywords = "Bone cement replacement, Drug release, In-situ forming hydrogels",
author = "K{\'a}roly Wellinger and Hristifor G{\'a}lity and K{\'a}lm{\'a}n T{\'o}th and P. Szab{\'o}-R{\'e}v{\'e}sz and E. Urb{\'a}n and Erzs{\'e}bet Cs{\'a}nyi",
year = "2012",
language = "English",
volume = "60",
pages = "711--720",
journal = "Farmacia",
issn = "0014-8237",
publisher = "Romanian Society for Pharmaceutical Sciences",
number = "5",

}

TY - JOUR

T1 - Ofloxacin loaded, in-situ - Gelling, calcium alginate hydrogel in the local treatment of bone and soft tissue infections in orthopaedic surgery

AU - Wellinger, Károly

AU - Gálity, Hristifor

AU - Tóth, Kálmán

AU - Szabó-Révész, P.

AU - Urbán, E.

AU - Csányi, Erzsébet

PY - 2012

Y1 - 2012

N2 - Nowadays in orthopedic surgery -in the treatment of bone and soft tissue infections-there is an increasing claim for improving biodegradable drug delivery systems that can be easily placed into the site of application instead of the currently applied polymethylmethacrylate (PMMA) bone cements, since PMMA has some undesirable side effects. Therefore the aim of the study was to develop an injectable, Ofloxacin-loaded, calcium-crosslinked sodium-alginate based drug delivery system, for local administration of antibiotics. It forms an elastic gel within a short time after injection, while its sustained drug release is controlled by a biodegradable polymer network. In vitro Franz vertical cell diffusion test and in vitro microbiological evaluation of the drug release suggested, that calcium-crosslinked sodium-alginate hydrogels are good candidates for replacement of the currently used non-biodegradable bone cements in certain circumstances.

AB - Nowadays in orthopedic surgery -in the treatment of bone and soft tissue infections-there is an increasing claim for improving biodegradable drug delivery systems that can be easily placed into the site of application instead of the currently applied polymethylmethacrylate (PMMA) bone cements, since PMMA has some undesirable side effects. Therefore the aim of the study was to develop an injectable, Ofloxacin-loaded, calcium-crosslinked sodium-alginate based drug delivery system, for local administration of antibiotics. It forms an elastic gel within a short time after injection, while its sustained drug release is controlled by a biodegradable polymer network. In vitro Franz vertical cell diffusion test and in vitro microbiological evaluation of the drug release suggested, that calcium-crosslinked sodium-alginate hydrogels are good candidates for replacement of the currently used non-biodegradable bone cements in certain circumstances.

KW - Bone cement replacement

KW - Drug release

KW - In-situ forming hydrogels

UR - http://www.scopus.com/inward/record.url?scp=84867496940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867496940&partnerID=8YFLogxK

M3 - Article

VL - 60

SP - 711

EP - 720

JO - Farmacia

JF - Farmacia

SN - 0014-8237

IS - 5

ER -