Ofloxacin loaded, in-situ - Gelling, calcium alginate hydrogel in the local treatment of bone and soft tissue infections in orthopaedic surgery

Károly Wellinger, Hristifor Gálity, Kálmán Tóth, Piroska Szabó-Révész, Edit Urbán, Erzsébet Csányi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nowadays in orthopedic surgery -in the treatment of bone and soft tissue infections-there is an increasing claim for improving biodegradable drug delivery systems that can be easily placed into the site of application instead of the currently applied polymethylmethacrylate (PMMA) bone cements, since PMMA has some undesirable side effects. Therefore the aim of the study was to develop an injectable, Ofloxacin-loaded, calcium-crosslinked sodium-alginate based drug delivery system, for local administration of antibiotics. It forms an elastic gel within a short time after injection, while its sustained drug release is controlled by a biodegradable polymer network. In vitro Franz vertical cell diffusion test and in vitro microbiological evaluation of the drug release suggested, that calcium-crosslinked sodium-alginate hydrogels are good candidates for replacement of the currently used non-biodegradable bone cements in certain circumstances.

Original languageEnglish
Pages (from-to)711-720
Number of pages10
JournalFarmacia
Volume60
Issue number5
Publication statusPublished - Oct 22 2012

Keywords

  • Bone cement replacement
  • Drug release
  • In-situ forming hydrogels

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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