Ocular pigmented findings in patients with dysplastic naevus syndrome

Edit Toth-Molnar, Judit Olah, Attila Dobozy, Helga Hammer

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

There is a growing body of evidence supporting the theory that cutaneous dysplastic naevus syndrome patients are at increased risk of developing not only skin but also uveal melanoma. The relationship between dysplastic naevus syndrome and ocular naevi needs to be clarified. In this study we investigated the ocular pigmented findings in patients with dysplastic naevus syndrome and compared the results with a control group (subjects without atypical moles) in order to investigate the frequency of ocular naevi among dysplastic naevi-bearing patients. A total of 152 dysplastic naevus syndrome patients were enrolled in our investigation. The control group consisted of 142 sex-, age- and skin type-matched healthy volunteers without cutaneous dysplastic naevi or skin melanoma. Conjunctival and uveal pigmented findings and iris colour were recorded during a detailed ophthalmic examination. A greater number of conjunctival naevi (3.2% versus 0%), iris naevi (5.2% versus 1.4%), iris freckles (17% versus 5.6%) and choroldal naevi (5.2% versus 0.7%) were detected in the dysplastic naevus syndrome group compared with the controls. The difference reached statistical significance in the case of conjunctival naevi, choroidal naevi and iris freckles. Our results confirm the hypothesis that dysplastic naevus syndrome patients might have overstimulation of their melanocytic system not only in the skin but also in the uvea, leading to increased benign (as well as rarely malignant) melanocytic proliferation. Dysplastic naevus syndrome patients should be screened by ophthalmologists because of the increased frequency of different ocular pigmented alterations.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalMelanoma research
Volume14
Issue number1
DOIs
Publication statusPublished - Feb 2004

    Fingerprint

Keywords

  • Choroidal naevi
  • Conjunctival naevi
  • Dysplastic naevi
  • Iris naevi

ASJC Scopus subject areas

  • Oncology
  • Dermatology
  • Cancer Research

Cite this