Octreotide-induced drinking, vasopressin, and pressure responses: Role of central angiotensin and ACh

I. Hajdu, F. Obál, J. Gardi, F. Laczi, J. M. Krueger

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The involvement of central angiotensinergic and cholinergic mechanisms in the effects of the intracerebroventricularly injected somatostatin analog octreotide (Oct) on drinking, blood pressure, and vasopressin secretion in the rat was investigated. Intracerebroventricular Oct elicited prompt drinking lasting for 10 min. Water consumption depended on the dose of Oct (0.01, 0.1, and 0.4 μg). The drinking response to Oct was inhibited by pretreatments with the intracerebroventricularly injected angiotensin-converting enzyme inhibitor captopril, the AT1/AT2 angiotensin receptor antagonist saralasin, the selective AT1 receptor antagonist losartan, or the muscarinic cholinergic receptor antagonist atropine. The dipsogenic effect of Oct was not altered by prior subcutaneous injection of naloxone. Oct stimulated vasopressin secretion and enhanced blood pressure. These responses were also blocked by pretreatments with captopril or atropine. Previous reports indicate that the central angiotensinergic and cholinergic mechanisms stimulate drinking and vasopressin secretion independently. We suggest that somatostatin acting on sst2 or sst5 receptors modulates central angiotensinergic and cholinergic mechanisms involved in the regulation of fluid balance.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume279
Issue number1 48-1
Publication statusPublished - 2000

Fingerprint

Octreotide
Angiotensins
Vasopressins
Drinking
Pressure
Cholinergic Agents
Captopril
Somatostatin
Atropine
Saralasin
Blood Pressure
Water-Electrolyte Balance
Losartan
Angiotensin Receptor Antagonists
Cholinergic Antagonists
Muscarinic Receptors
Subcutaneous Injections
Naloxone
Angiotensin-Converting Enzyme Inhibitors

Keywords

  • Blood pressure
  • Cholinergic
  • Muscarinic
  • Rat
  • Somatostatin
  • Thirst

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Octreotide-induced drinking, vasopressin, and pressure responses : Role of central angiotensin and ACh. / Hajdu, I.; Obál, F.; Gardi, J.; Laczi, F.; Krueger, J. M.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 279, No. 1 48-1, 2000.

Research output: Contribution to journalArticle

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