Octopamine- and dopamine-sensitive adenylate cyclase in the brain of Locusta migratoria during its development

L. Hiripi, Katalin S.-Rozsa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

1. Octopamine- and dopamine-sensitive adenylate cyclases were studied in the brain of Locusta migratoria during its metamorphosis. In the adult brain the effects of octopamine and dopamine on adenylate cyclase were additive, suggesting the presence of separate populations of adenylate cyclase-linked receptors for octopamine and dopamine. There are no separate receptors for noradrenaline. 2. Octopamine stimulates adenylate cyclase in both adult and larval brain; however, in adult brain octopamine is more potent than in larval brain. Dopamine stimulates adenylate cyclase activity only in adult brain. The sensitivity of adenylate cyclase to octopamine changes during the development of the animal. 3. Phentolamine and cyproheptadine are potent antagonists of octopaminestimulated adenylate cyclase, while propanolol has a weak effect. 4. No cytosol factor which would modulate either basal or octopaminestimulated adenylate cyclase was found. 5. The effect of GTP and octopamine on adenylate cyclase was synergistic in adult brain but not in larval brain, while the effect of GppNHp and octopamine was synergistic in both adult and larval brains.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalCellular and Molecular Neurobiology
Volume4
Issue number3
DOIs
Publication statusPublished - Sep 1984

Fingerprint

Octopamine
Locusta migratoria
Adenylyl Cyclases
Dopamine
Brain
Cyproheptadine
Phentolamine
Dopamine Receptors
Guanosine Triphosphate
Propranolol
Cytosol
Norepinephrine
Animals

Keywords

  • adenylate cyclase
  • dopamine
  • insect brain
  • metamorphosis
  • octopamine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Octopamine- and dopamine-sensitive adenylate cyclase in the brain of Locusta migratoria during its development. / Hiripi, L.; S.-Rozsa, Katalin.

In: Cellular and Molecular Neurobiology, Vol. 4, No. 3, 09.1984, p. 199-206.

Research output: Contribution to journalArticle

@article{736abfe5453149a5893e0aeb92925e0c,
title = "Octopamine- and dopamine-sensitive adenylate cyclase in the brain of Locusta migratoria during its development",
abstract = "1. Octopamine- and dopamine-sensitive adenylate cyclases were studied in the brain of Locusta migratoria during its metamorphosis. In the adult brain the effects of octopamine and dopamine on adenylate cyclase were additive, suggesting the presence of separate populations of adenylate cyclase-linked receptors for octopamine and dopamine. There are no separate receptors for noradrenaline. 2. Octopamine stimulates adenylate cyclase in both adult and larval brain; however, in adult brain octopamine is more potent than in larval brain. Dopamine stimulates adenylate cyclase activity only in adult brain. The sensitivity of adenylate cyclase to octopamine changes during the development of the animal. 3. Phentolamine and cyproheptadine are potent antagonists of octopaminestimulated adenylate cyclase, while propanolol has a weak effect. 4. No cytosol factor which would modulate either basal or octopaminestimulated adenylate cyclase was found. 5. The effect of GTP and octopamine on adenylate cyclase was synergistic in adult brain but not in larval brain, while the effect of GppNHp and octopamine was synergistic in both adult and larval brains.",
keywords = "adenylate cyclase, dopamine, insect brain, metamorphosis, octopamine",
author = "L. Hiripi and Katalin S.-Rozsa",
year = "1984",
month = "9",
doi = "10.1007/BF00733585",
language = "English",
volume = "4",
pages = "199--206",
journal = "Cellular and Molecular Neurobiology",
issn = "0272-4340",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Octopamine- and dopamine-sensitive adenylate cyclase in the brain of Locusta migratoria during its development

AU - Hiripi, L.

AU - S.-Rozsa, Katalin

PY - 1984/9

Y1 - 1984/9

N2 - 1. Octopamine- and dopamine-sensitive adenylate cyclases were studied in the brain of Locusta migratoria during its metamorphosis. In the adult brain the effects of octopamine and dopamine on adenylate cyclase were additive, suggesting the presence of separate populations of adenylate cyclase-linked receptors for octopamine and dopamine. There are no separate receptors for noradrenaline. 2. Octopamine stimulates adenylate cyclase in both adult and larval brain; however, in adult brain octopamine is more potent than in larval brain. Dopamine stimulates adenylate cyclase activity only in adult brain. The sensitivity of adenylate cyclase to octopamine changes during the development of the animal. 3. Phentolamine and cyproheptadine are potent antagonists of octopaminestimulated adenylate cyclase, while propanolol has a weak effect. 4. No cytosol factor which would modulate either basal or octopaminestimulated adenylate cyclase was found. 5. The effect of GTP and octopamine on adenylate cyclase was synergistic in adult brain but not in larval brain, while the effect of GppNHp and octopamine was synergistic in both adult and larval brains.

AB - 1. Octopamine- and dopamine-sensitive adenylate cyclases were studied in the brain of Locusta migratoria during its metamorphosis. In the adult brain the effects of octopamine and dopamine on adenylate cyclase were additive, suggesting the presence of separate populations of adenylate cyclase-linked receptors for octopamine and dopamine. There are no separate receptors for noradrenaline. 2. Octopamine stimulates adenylate cyclase in both adult and larval brain; however, in adult brain octopamine is more potent than in larval brain. Dopamine stimulates adenylate cyclase activity only in adult brain. The sensitivity of adenylate cyclase to octopamine changes during the development of the animal. 3. Phentolamine and cyproheptadine are potent antagonists of octopaminestimulated adenylate cyclase, while propanolol has a weak effect. 4. No cytosol factor which would modulate either basal or octopaminestimulated adenylate cyclase was found. 5. The effect of GTP and octopamine on adenylate cyclase was synergistic in adult brain but not in larval brain, while the effect of GppNHp and octopamine was synergistic in both adult and larval brains.

KW - adenylate cyclase

KW - dopamine

KW - insect brain

KW - metamorphosis

KW - octopamine

UR - http://www.scopus.com/inward/record.url?scp=0021745753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021745753&partnerID=8YFLogxK

U2 - 10.1007/BF00733585

DO - 10.1007/BF00733585

M3 - Article

VL - 4

SP - 199

EP - 206

JO - Cellular and Molecular Neurobiology

JF - Cellular and Molecular Neurobiology

SN - 0272-4340

IS - 3

ER -