Ochratoxin a

Molecular interactions, mechanisms of toxicity and prevention at the molecular level

T. Kőszegi, Miklós Poór

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Ochratoxin A (OTA) is a widely-spread mycotoxin all over the world causing major health risks. The focus of the present review is on the molecular and cellular interactions of OTA. In order to get better insight into the mechanism of its toxicity and on the several attempts made for prevention or attenuation of its toxic action, a detailed description is given on chemistry and toxicokinetics of this mycotoxin. The mode of action of OTA is not clearly understood yet, and seems to be very complex. Inhibition of protein synthesis and energy production, induction of oxidative stress, DNA adduct formation, as well as apoptosis/necrosis and cell cycle arrest are possibly involved in its toxic action. Since OTA binds very strongly to human and animal albumin, a major emphasis is done regarding OTA-albumin interaction. Displacement of OTA from albumin by drugs and by natural flavonoids are discussed in detail, hypothesizing their potentially beneficial effect in order to prevent or attenuate the OTA-induced toxic consequences.

Original languageEnglish
Article number111
JournalToxins
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 15 2016

Fingerprint

Ochratoxins
Molecular interactions
Toxicity
Toxic Actions
Albumins
Mycotoxins
Oxidative stress
DNA Adducts
Poisons
Health risks
Cell Cycle Checkpoints
ochratoxin A
Flavonoids
Animals
Oxidative Stress
Necrosis
Cells
Apoptosis
Health
Pharmaceutical Preparations

Keywords

  • Albumin binding
  • Cellular effects
  • Flavonoids
  • Nephropathy
  • Ochratoxin A
  • Prevention
  • Toxicokinetics

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Ochratoxin a : Molecular interactions, mechanisms of toxicity and prevention at the molecular level. / Kőszegi, T.; Poór, Miklós.

In: Toxins, Vol. 8, No. 4, 111, 15.04.2016.

Research output: Contribution to journalArticle

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