Ochratoxin A content of human sera determined by a sensitive ELISA

László Solti, Ferenc Salamon, Ildikó Barna-Vetró, Ágnes Gyöngyösi, Erzsébet Szabó, Anna Wölfling

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A sensitive, monoclonal antibody-based ELISA test was developed and used for quantitative determination of ochratoxin A (OA) in human sera. The measuring range of this test (without sample dilution) was 0.2-2.0 ng/mL, and the detection limit was 0.2 ng/mL. The OA concentrations of 355 sera samples varied from <0.2 to 10 ng/mL OA, but 75% of the samples contained 0.2-1.0 ng/mL. This amount reflects a tolerable daily intake (TDI) value of toxin. However, in some cases (6.8%), more than 1.0 ng/mL OA was measured, which is probably a result of elevated intake of OA, which may even exceed the 'virtually safe dose'. Our data indicate that, like in many other countries, OA is present in food or feed products available in Hungary, and in order to save the health of consumers, their regular control is desirable.

Original languageEnglish
Pages (from-to)44-48
Number of pages5
JournalJournal of Analytical Toxicology
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 1997

ASJC Scopus subject areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

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