Occurrence of osteopenia among adolescent girls with oligo / amenorrhea

T. Csermely, L. Halvax, E. Schmidt, K. Zámbó, G. Vadon, I. Szabó, A. Szilágyi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The occurrence of reduced bone mineral density (BMD) among adolescent girls with oligomenorrhea or secondary amenorrhea, due to 'pure' dysfunction of the hypothalamo-pituitary-ovarian (HPO) axis (without anorexia nervosa, excessive sport or ballet, slimming diet, etc.) was examined. The study group consisted of 19 adolescent girls (age 16-18 years) with oligo/amenorrhea. Clinical (height, weight, age at menarche, duration of amenorrhea, body mass index (BMI)), hormonal (follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, testosterone, prolactin), and ion (calcium, sodium, potassium, phosphate, chloride) parameters and the BMD of the lumbar spine were investigated. Correlations between BMD and other parameters were also examined. Twenty healthy volunteers (same age and regular cycles) sewed as controls. Three girls had osteoporosis, with a BMD below-2 standard deviations (SD). Ten showed osteopenia, with a BMD value between -1 and -2 SD. Only six of the study group had a normal BMD within ± 1 SD. A positive correlation was observed between the BMD and the BMI (r = 0.73; p <0.05). All the controls had normal hormonal, ion and BMD parameters. 'Pure' dysfunction of the HPO axis in adolescents, causing oligomenorrhea or secondary amenorrhea, might result in reduced BMD and, consequently, lower peak bone mass. Treatment of menstrual cycle disorders is necessary for the prevention of osteoporosis.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalGynecological Endocrinology
Volume16
Issue number2
Publication statusPublished - 2002

Fingerprint

Metabolic Bone Diseases
Amenorrhea
Bone Density
Oligomenorrhea
Osteoporosis
Body Mass Index
Dancing
Ions
Menarche
Potassium Chloride
Anorexia Nervosa
Follicle Stimulating Hormone
Menstrual Cycle
Luteinizing Hormone
Prolactin
Sports
Progesterone
Testosterone
Estradiol
Healthy Volunteers

Keywords

  • Adolescent
  • Bone Mineral Density
  • Oligo/Amenorrhea
  • Osteopenia

ASJC Scopus subject areas

  • Endocrinology
  • Obstetrics and Gynaecology

Cite this

Csermely, T., Halvax, L., Schmidt, E., Zámbó, K., Vadon, G., Szabó, I., & Szilágyi, A. (2002). Occurrence of osteopenia among adolescent girls with oligo / amenorrhea. Gynecological Endocrinology, 16(2), 99-105.

Occurrence of osteopenia among adolescent girls with oligo / amenorrhea. / Csermely, T.; Halvax, L.; Schmidt, E.; Zámbó, K.; Vadon, G.; Szabó, I.; Szilágyi, A.

In: Gynecological Endocrinology, Vol. 16, No. 2, 2002, p. 99-105.

Research output: Contribution to journalArticle

Csermely, T, Halvax, L, Schmidt, E, Zámbó, K, Vadon, G, Szabó, I & Szilágyi, A 2002, 'Occurrence of osteopenia among adolescent girls with oligo / amenorrhea', Gynecological Endocrinology, vol. 16, no. 2, pp. 99-105.
Csermely T, Halvax L, Schmidt E, Zámbó K, Vadon G, Szabó I et al. Occurrence of osteopenia among adolescent girls with oligo / amenorrhea. Gynecological Endocrinology. 2002;16(2):99-105.
Csermely, T. ; Halvax, L. ; Schmidt, E. ; Zámbó, K. ; Vadon, G. ; Szabó, I. ; Szilágyi, A. / Occurrence of osteopenia among adolescent girls with oligo / amenorrhea. In: Gynecological Endocrinology. 2002 ; Vol. 16, No. 2. pp. 99-105.
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